Durable HIV RNA resuppression after virologic failure while remaining on a first-line regimen: A cohort study

Christopher J. Hoffmann, Salome Charalambous, Alison D. Grant, Lynn Morris, Gavin J. Churchyard, Richard E. Chaisson

Research output: Contribution to journalArticlepeer-review

Abstract

Summary: Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.

Original languageEnglish (US)
Pages (from-to)236-239
Number of pages4
JournalTropical Medicine and International Health
Volume19
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Adherence
  • Africa
  • Antiretroviral therapy
  • Clinical management
  • HIV
  • Treatment failure

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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