Duodenal reflux produces hyperproliferative epithelial esophagitis - A possible precursor to esophageal adenocarcinoma in the rat

Colman K. Byrnes, Anil Bahadursingh, Nabeel Akhter, Narasimham L. Parinandi, Viswanathan Natarajan, Elizabeth A Montgomery, Tarik Tihan, Mark D Duncan, Petra H. Nass, John Harmon

Research output: Contribution to journalArticle

Abstract

Esophageal reflux of duodenal contents converts a rat nitrosamine esophageal cancer model from squamous cell carcinoma to adenocarcinoma. Further, there was a tendency for male rats to have a higher incidence of cancer than female rats. However, chemical castration with the gonadotropin-releasing hormone analog leuprolide did not protect male or female animals from developing cancer. We have identified an early (6-week) hyperproliferative epithelial cell reaction to duodenal reflux. We carried out experiments to assess the specificity of duodenal reflux in producing the hyperproliferative epithelial precursor lesion. Animals underwent specific surgical procedures to produce esophageal reflux of pure duodenal contents, mixed gastroduodenal, or bland intestinal contents. A hyperproliferative mucosal esophagitis developed in the group with duodenal reflux but not in the other groups. Mucosal thickness in the duodenal reflux group reached seven times that of normal mucosa at 6 weeks. These results suggest that esophageal reflux of duodenal contents plays an important role in the pathogenicity of proliferative esophagitis and the potential development of esophageal adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)172-180
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume7
Issue number2
DOIs
StatePublished - Feb 2003

Fingerprint

Duodenogastric Reflux
Esophagitis
Adenocarcinoma
Gastroesophageal Reflux
Leuprolide
Nitrosamines
Gastrointestinal Contents
Castration
Esophageal Neoplasms
Gonadotropin-Releasing Hormone
Virulence
Squamous Cell Carcinoma
Neoplasms
Mucous Membrane
Epithelial Cells
Incidence

Keywords

  • Esophageal cancer
  • Gastroesophageal reflux disease (GERD)
  • Leuprolide
  • N-acetylcysteine
  • Rat

ASJC Scopus subject areas

  • Surgery

Cite this

Duodenal reflux produces hyperproliferative epithelial esophagitis - A possible precursor to esophageal adenocarcinoma in the rat. / Byrnes, Colman K.; Bahadursingh, Anil; Akhter, Nabeel; Parinandi, Narasimham L.; Natarajan, Viswanathan; Montgomery, Elizabeth A; Tihan, Tarik; Duncan, Mark D; Nass, Petra H.; Harmon, John.

In: Journal of Gastrointestinal Surgery, Vol. 7, No. 2, 02.2003, p. 172-180.

Research output: Contribution to journalArticle

Byrnes, Colman K. ; Bahadursingh, Anil ; Akhter, Nabeel ; Parinandi, Narasimham L. ; Natarajan, Viswanathan ; Montgomery, Elizabeth A ; Tihan, Tarik ; Duncan, Mark D ; Nass, Petra H. ; Harmon, John. / Duodenal reflux produces hyperproliferative epithelial esophagitis - A possible precursor to esophageal adenocarcinoma in the rat. In: Journal of Gastrointestinal Surgery. 2003 ; Vol. 7, No. 2. pp. 172-180.
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