TY - JOUR
T1 - Dual-positive CD4/CD8 primary cutaneous peripheral T-cell lymphoma previously classified as mycosis fungoides a tumor d’emblée
AU - Raychaudhuri, Sreejata
AU - Rahvar, Maral
AU - Jedrych, Jaroslaw
AU - Karunamurthy, Arivarasan
AU - Kruglov, Oleg
AU - Rakfal, Susan
AU - Kane, Kevin
AU - Akilov, Oleg E.
N1 - Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Cutaneous peripheral T-cell lymphoma, not otherwise specified represents a “waste basket” of all cases that cannot be put into another of the categories of mature cutaneous T-cell lymphoma. Previously, the sudden multifocal development of cutaneous CD4+ tumors without preceding a patch or plaque stage was classified as d’emblée form of mycosis fungoides (MF). Currently, the term “MF” reserved only for the classic Alibert–Bazin type characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. The authors describe a 75-year-old white woman who presented with a solitary skin tumor in the right supraclavicular region, with no lymph node or systemic involvement. Local external beam radiation treatment resulted in a complete response. The patient relapsed after 5 months with new tumors in the left neck and left upper chest. Biopsy of the lesions showed a dermal infiltrate of atypical small- to medium-sized T-lymphocytes, and immunohistochemical staining showed coexpression of CD4/CD8 in a subset of these cells, which was confirmed with flow cytometry of the tumor. Although the patient had no preceding patch or plaque stage, the authors herein report this extremely rare case of CD4/CD8 dual-positive peripheral T-cell lymphoma, not otherwise specified presented as MF d’emblée and discuss the seldom similar cases published previously.
AB - Cutaneous peripheral T-cell lymphoma, not otherwise specified represents a “waste basket” of all cases that cannot be put into another of the categories of mature cutaneous T-cell lymphoma. Previously, the sudden multifocal development of cutaneous CD4+ tumors without preceding a patch or plaque stage was classified as d’emblée form of mycosis fungoides (MF). Currently, the term “MF” reserved only for the classic Alibert–Bazin type characterized by the evolution of patches, plaques, and tumors or for variants showing a similar clinical course. The authors describe a 75-year-old white woman who presented with a solitary skin tumor in the right supraclavicular region, with no lymph node or systemic involvement. Local external beam radiation treatment resulted in a complete response. The patient relapsed after 5 months with new tumors in the left neck and left upper chest. Biopsy of the lesions showed a dermal infiltrate of atypical small- to medium-sized T-lymphocytes, and immunohistochemical staining showed coexpression of CD4/CD8 in a subset of these cells, which was confirmed with flow cytometry of the tumor. Although the patient had no preceding patch or plaque stage, the authors herein report this extremely rare case of CD4/CD8 dual-positive peripheral T-cell lymphoma, not otherwise specified presented as MF d’emblée and discuss the seldom similar cases published previously.
KW - CD4 CD8 double positive
KW - Cutaneous lymphoma
KW - Mycosis fungoides a tumor d’emblée
KW - NOS
KW - PTCL
KW - Tumor
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U2 - 10.1097/DAD.0000000000001188
DO - 10.1097/DAD.0000000000001188
M3 - Article
C2 - 29794483
AN - SCOPUS:85055076248
SN - 0193-1091
VL - 40
SP - 836
EP - 840
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 11
ER -