Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans

Andrew W. Artenstein; Thomas C. Van Cott; John R. Mascola; Jean K. Carr; Patricia A. Hegerich; Jariyanart Gaywee; Eric Sanders-Buell; Merlin L. Robb; Debora E. Dayhoff; Sataporn Thitivichianlert; Sorachai Nitayaphan; John G. Mc Neil; Deborah L. Birx; Rodney A. Michael; Donald S. Burke; Francine E. Mc Cutchan

doi:10.1093/infdis/171.4.805

Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans

Andrew W. Artenstein, Thomas C. Van Cott, John R. Mascola, Jean K. Carr, Patricia A. Hegerich, Jariyanart Gaywee, Eric Sanders-Buell, Merlin L. Robb, Debora E. Dayhoff, Sataporn Thitivichianlert, Sorachai Nitayaphan, John G. Mc Neil, Deborah L. Birx, Rodney A. Michael, Donald S. Burke, Francine E. Mc Cutchan

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Multiple genetic subtypes of human immunodeficiency virus type 1 (HIV-1) have been identified among internationally collected isolates. The HIV-1 epidemic in Thailand is largely due to B and E subtypes of virus. Dual infection with distinct HIV-1 subtypes would suggest that antiviral immunity evoked by one subtype can be incompletely protective against a second. Polymerase chain reaction typing and serologic typing were used to screen a panel of specimens from HIV-1infected subjects in Thailand. Two persons simultaneously harbored HIV-1 of env subtypes B and E, and this was confirmed by colony hybridization with subtype-specific probes and nucleotide sequence analysis of a 630-bp fragment of gp120 from multiple molecular clones. In addition, both subtypes were identified in cocultured peripheral blood mononuclear cells from 1 individual. These data provide the first evidence of dual HIV-1 infection in humans and reinforce the need for polyvalent vaccines.

Original language	English (US)
Pages (from-to)	805-810
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	171
Issue number	4
DOIs	https://doi.org/10.1093/infdis/171.4.805
State	Published - Apr 1995

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Artenstein, A. W., Van Cott, T. C., Mascola, J. R., Carr, J. K., Hegerich, P. A., Gaywee, J., Sanders-Buell, E., Robb, M. L., Dayhoff, D. E., Thitivichianlert, S., Nitayaphan, S., Mc Neil, J. G., Birx, D. L., Michael, R. A., Burke, D. S., & Mc Cutchan, F. E. (1995). Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans. Journal of Infectious Diseases, 171(4), 805-810. https://doi.org/10.1093/infdis/171.4.805

Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans. / Artenstein, Andrew W.; Van Cott, Thomas C.; Mascola, John R.; Carr, Jean K.; Hegerich, Patricia A.; Gaywee, Jariyanart; Sanders-Buell, Eric; Robb, Merlin L.; Dayhoff, Debora E.; Thitivichianlert, Sataporn; Nitayaphan, Sorachai; Mc Neil, John G.; Birx, Deborah L.; Michael, Rodney A.; Burke, Donald S.; Mc Cutchan, Francine E.

In: Journal of Infectious Diseases, Vol. 171, No. 4, 04.1995, p. 805-810.

Research output: Contribution to journal › Article › peer-review

Artenstein, AW, Van Cott, TC, Mascola, JR, Carr, JK, Hegerich, PA, Gaywee, J, Sanders-Buell, E, Robb, ML, Dayhoff, DE, Thitivichianlert, S, Nitayaphan, S, Mc Neil, JG, Birx, DL, Michael, RA, Burke, DS & Mc Cutchan, FE 1995, 'Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans', Journal of Infectious Diseases, vol. 171, no. 4, pp. 805-810. https://doi.org/10.1093/infdis/171.4.805

Artenstein, Andrew W. ; Van Cott, Thomas C. ; Mascola, John R. ; Carr, Jean K. ; Hegerich, Patricia A. ; Gaywee, Jariyanart ; Sanders-Buell, Eric ; Robb, Merlin L. ; Dayhoff, Debora E. ; Thitivichianlert, Sataporn ; Nitayaphan, Sorachai ; Mc Neil, John G. ; Birx, Deborah L. ; Michael, Rodney A. ; Burke, Donald S. ; Mc Cutchan, Francine E. / Dual infection with human immunodeficiency virus type 1 of distinct envelope subtypes in humans. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 4. pp. 805-810.

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abstract = "Multiple genetic subtypes of human immunodeficiency virus type 1 (HIV-1) have been identified among internationally collected isolates. The HIV-1 epidemic in Thailand is largely due to B and E subtypes of virus. Dual infection with distinct HIV-1 subtypes would suggest that antiviral immunity evoked by one subtype can be incompletely protective against a second. Polymerase chain reaction typing and serologic typing were used to screen a panel of specimens from HIV-1infected subjects in Thailand. Two persons simultaneously harbored HIV-1 of env subtypes B and E, and this was confirmed by colony hybridization with subtype-specific probes and nucleotide sequence analysis of a 630-bp fragment of gp120 from multiple molecular clones. In addition, both subtypes were identified in cocultured peripheral blood mononuclear cells from 1 individual. These data provide the first evidence of dual HIV-1 infection in humans and reinforce the need for polyvalent vaccines.",

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