Dual imaging ofarterial walls: Intravascular ultrasound and fluorescence spectroscopy

Karl Pope, Steve Warren, Youseph Yazdi, Alfred Johnston, Michael Davis, Rebecca Richards Kortum

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

This paper describes a combined ultrasonic and spectroscopic system for imaging both the structure and chemical composition of atherosclerotic plaque. Using this system, ultrasound pulse echo distance estimations can be used to accurately compensate detected tissue fluorescence intensities for a wide range of tissue-detector separations, D. Compensation is achieved using an empirical model, wherein fluorescence intensity decreases as lID" with n=1.1 for tissue detector separations from 2.5 to 5 mm and 1.4 for separations of 5 to 15 mm. This behavior indicates that fluorescence exiting the tissue surface is not isotropic.

Original languageEnglish (US)
Pages (from-to)42-50
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1878
DOIs
StatePublished - Jun 23 1993
Externally publishedYes
EventDiagnostic and Therapeutic Cardiovascular Interventions III 1993 - Los Angeles, United States
Duration: Jan 17 1993Jan 22 1993

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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