Dual HIV-1 infection associated with rapid disease progression

Geoffrey S. Gottlieb, David C. Nickle, Mark A. Jensen, Kim G. Wong, Jandre Grobler, Fusheng Li, Shan Lu Liu, Cecilia Rademeyer, Gerald H. Learn, Salim S.Abdool Karim, Carolyn Williamson, Lawrence Corey, Joseph B. Margolick, James I. Mullins

Research output: Contribution to journalArticle

Abstract

Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid (<3.4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.

Original languageEnglish (US)
Pages (from-to)619-622
Number of pages4
JournalLancet
Volume363
Issue number9409
DOIs
StatePublished - Feb 21 2004

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gottlieb, G. S., Nickle, D. C., Jensen, M. A., Wong, K. G., Grobler, J., Li, F., Liu, S. L., Rademeyer, C., Learn, G. H., Karim, S. S. A., Williamson, C., Corey, L., Margolick, J. B., & Mullins, J. I. (2004). Dual HIV-1 infection associated with rapid disease progression. Lancet, 363(9409), 619-622. https://doi.org/10.1016/S0140-6736(04)15596-7