Dual-band water and lipid suppression for MR spectroscopic imaging at 3 tesla

He Zhu, Ronald Ouwerkerk, Peter B. Barker

Research output: Contribution to journalArticle

Abstract

A dual-band water and lipid suppression sequence was developed for multislice sensitivity-encoded proton MR spectroscopic imaging of the human brain. The presaturation scheme consisted of five dual-band frequency-modulated radiofrequency pulses based on hypergeometric functions integrated with eight outer volume suppression (OVS) pulses. The flip angles of the dual-band pulses were optimized through computer simulations to maximize suppression factors over a range of transmitter amplitude of radiofrequency field and water and lipid T1 values. The resulting hypergeometric dual band with OVS (HGDB + OVS) sequence was implemented at 3 T in a multislice sensitivity-encoded proton MR spectroscopic imaging experiment and compared to a conventional water suppression scheme (variable pulse power and optimized relaxation delays (VAPOR)) with OVS. The HGDB sequence was significantly shorter than the VAPOR sequence (230 versus 728 msec). Both HGDB + OVS and VAPOR + OVS produced good water suppression, while lipid suppression with the HGDB + OVS sequence was far superior. In sensitivity-encoded proton MR spectroscopic imaging data, artifacts from extracranial lipid signals were significantly lower with HGDB + OVS. The shorter duration of HGDB compared to VAPOR also allows reduced pulse repetition time values in the multislice acquisition.

Original languageEnglish (US)
Pages (from-to)1486-1492
Number of pages7
JournalMagnetic resonance in medicine
Volume63
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Brain
  • Lipid suppression
  • Magnetic resonance spectroscopic imaging
  • Sensitivity-encoding
  • Water suppression

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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