Drugs for a new millennium

Research output: Contribution to journalArticlepeer-review

Abstract

A millennium, a century, even a decade is a long time-frame for speculation about anything. Advances in biomedical research in the last few decades have been so extraordinary and escalating at an ever-accelerating pace that any prophecy is a risky proposition. However, it is possible to divine the big, unanswered questions and envisage ways in which they might reasonably be approached in the next few decades, a task which I will try to essay. So many drugs treat so many different medical conditions that a detailed and comprehensive coverage would probably be tiresome. Instead, I will address certain broad themes and diseases that offer both immense challenges and great potential for advances. Rather than review detailed experimental issues, I will confine myself to the 'big picture' issues, providing examples of specific research only in a few instances drawing largely from areas I know best.

Original languageEnglish (US)
Pages (from-to)1985-1994
Number of pages10
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume354
Issue number1392
DOIs
StatePublished - Dec 29 1999

Keywords

  • Antidepressants
  • Cocaine
  • Neuroleptics
  • Nitric oxide
  • Poly(ADP-ribose) polymerase
  • Schizophrenia

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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