DrugPath: A database for academic investigators to match oncology molecular targets with drugs in development

Eric D. Shah, Brandon M.A. Fisch, Robert J. Arceci, Jonathan D. Buckley, Gregory H. Reaman, Poul H. Sorensen, Timothy J. Triche, C. Patrick Reynolds

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Academic laboratories are developing increasingly large amounts of data that describe the genomic landscape and gene expression patterns of various types of cancers. Such data can potentially identify novel oncology molecular targets in cancer types that may not be the primary focus of a drug sponsor's initial research for an investigational new drug. Obtaining preclinical data that point toward the potential for a given molecularly targeted agent, or a novel combination of agents requires knowledge of drugs currently in development in both the academic and commercial sectors. Methods: We have developed the DrugPath database (http://www.drugpath.org) as a comprehensive, free-of-charge resource for academic investigators to identify agents being developed in academics or industry that may act against molecular targets of interest. DrugPath data on molecular targets overlay the Michigan Molecular Interactions (http://mimi.ncibi.org) gene-gene interaction map to facilitate identification of related agents in the same pathway. Results: The database catalogs 2,081 drug development programs representing 751 drug sponsors and 722 molecular and genetic targets. Conclusions: DrugPath should assist investigators in identifying and obtaining drugs acting on specific molecular targets for biological and preclinical therapeutic studies.

Original languageEnglish (US)
Pages (from-to)1089-1093
Number of pages5
JournalCancer Chemotherapy and Pharmacology
Volume73
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Drug database
  • Drug development
  • Molecular target
  • Oncology

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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