Drug Therapy for Graves' Disease during Pregnancy

Harold Rosen, David F. Gardner, David S. Cooper, Naoko Momotani, Jaeduk Noh, Hiroshi Oyanagi, Naofumi Ishikawa, Kunihiko Ito

Research output: Contribution to journalLetterpeer-review


To the Editor: I greatly enjoyed reading the article by Momotani et al. (July 3 issue)* regarding antithyroid therapy for Graves' disease during pregnancy. There is, however, one comment that needs to be made. In their study, Momotani et al. found no difference between the group of women with hyperthyroidism treated with propylthiouracil and the group of women with hyperthyroidism treated with methimazole, in the proportion of fetuses with suppressed thyroid function. This was contrary to the investigators' expectations, since, “because of its reported limited placental transfer, propylthiouracil is widely preferred over methimazole.” One might be tempted to conclude that.

Original languageEnglish (US)
Pages (from-to)1485-1486
Number of pages2
JournalNew England Journal of Medicine
Issue number23
StatePublished - Dec 4 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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