Abstract
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug-resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-37 |
| Number of pages | 17 |
| Journal | Journal of Genetics and Genomics |
| Volume | 44 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 20 2017 |
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Keywords
- Drug target
- Mechanism
- Mycobacterium tuberculosis
- Resistance
- Tuberculosis
ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
Drug resistance mechanisms and novel drug targets for tuberculosis therapy. / Islam, Md Mahmudul; Hameed, H. M Adnan; Mugweru, Julius; Chhotaray, Chiranjibi; Wang, Changwei; Tan, Yaoju; Liu, Jianxiong; Li, Xinjie; Tan, Shouyong; Ojima, Iwao; Yew, Wing Wai; Nuermberger, Eric; Lamichhane, Gyanu; Zhang, Tianyu.
In: Journal of Genetics and Genomics, Vol. 44, No. 1, 20.01.2017, p. 21-37.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Drug resistance mechanisms and novel drug targets for tuberculosis therapy
AU - Islam,Md Mahmudul
AU - Hameed,H. M Adnan
AU - Mugweru,Julius
AU - Chhotaray,Chiranjibi
AU - Wang,Changwei
AU - Tan,Yaoju
AU - Liu,Jianxiong
AU - Li,Xinjie
AU - Tan,Shouyong
AU - Ojima,Iwao
AU - Yew,Wing Wai
AU - Nuermberger,Eric
AU - Lamichhane,Gyanu
AU - Zhang,Tianyu
PY - 2017/1/20
Y1 - 2017/1/20
N2 - Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug-resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.
AB - Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug-resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.
KW - Drug target
KW - Mechanism
KW - Mycobacterium tuberculosis
KW - Resistance
KW - Tuberculosis
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UR - http://www.scopus.com/inward/citedby.url?scp=85009108621&partnerID=8YFLogxK
U2 - 10.1016/j.jgg.2016.10.002
DO - 10.1016/j.jgg.2016.10.002
M3 - Review article
VL - 44
SP - 21
EP - 37
JO - Journal of Genetics and Genomics
T2 - Journal of Genetics and Genomics
JF - Journal of Genetics and Genomics
SN - 1673-8527
IS - 1
ER -