@article{19e52d3b042d4d6b9e1bd720fad4af78,
title = "Drug resistance mechanisms and novel drug targets for tuberculosis therapy",
abstract = "Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of the chemotherapy era. New insights into the resistant mechanisms of anti-TB drugs have been provided. Better understanding of drug resistance mechanisms helps in the development of new tools for the rapid diagnosis of drug-resistant TB. There is also a pressing need in the development of new drugs with novel targets to improve the current treatment of TB and to prevent the emergence of drug resistance in Mycobacterium tuberculosis. This review summarizes the anti-TB drug resistance mechanisms, furnishes some possible novel drug targets in the development of new agents for TB therapy and discusses the usefulness using known targets to develop new anti-TB drugs. Whole genome sequencing is currently an advanced technology to uncover drug resistance mechanisms in M. tuberculosis. However, further research is required to unravel the significance of some newly discovered gene mutations in their contribution to drug resistance.",
keywords = "Drug target, Mechanism, Mycobacterium tuberculosis, Resistance, Tuberculosis",
author = "Islam, {Md Mahmudul} and Hameed, {H. M.Adnan} and Julius Mugweru and Chiranjibi Chhotaray and Changwei Wang and Yaoju Tan and Jianxiong Liu and Xinjie Li and Shouyong Tan and Iwao Ojima and Yew, {Wing Wai} and Eric Nuermberger and Gyanu Lamichhane and Tianyu Zhang",
note = "Funding Information: This study was supported by the National Natural Science Foundation of China (No. 81572037), by the One Hundred Talents Program of the Chinese Academy of Sciences (Category A, to T.Z.), by the Open Project Grant (No. 2014SKLRD-O06) and the Key Project Grant (No. SKLRD2016ZJ003) from the State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, First Allied Hospital of Guangzhou Medical University, by the PhD Start-up Fund of Natural Science Foundation, Guangdong Province, China (No. 2016A030310123 to J.G.), by the Chinese Academy of Sciences-Commonwealth Scientific and Industrial Research Organization Mutual Grant (No. 154144KYSB20150045), and partially financed by Guangzhou Municipal Industry and Research Collaborative Innovation Program (Nos. 201508020248 and 201604020019) and Guangzhou Municipal Clinical Medical Center Program (No. 155700012). The study was also sponsored by CAS-TWAS President's PhD Fellowship Program (to M.M.I. and C.C.) and UCAS Fellowship Program (to H.M.A.H. and J.M.) for international PhD students. Publisher Copyright: {\textcopyright} 2016 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China",
year = "2017",
month = jan,
day = "20",
doi = "10.1016/j.jgg.2016.10.002",
language = "English (US)",
volume = "44",
pages = "21--37",
journal = "Journal of Genetics and Genomics",
issn = "1673-8527",
publisher = "Institute of Genetics and Developmental Biology",
number = "1",
}