Drug resistance always depends on the turnover rate

C. Tomasetti, D. Levy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations. A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate. In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.

Original languageEnglish (US)
Title of host publication26th Southern Biomedical Engineering Conference SBEC 2010
Pages552-555
Number of pages4
DOIs
StatePublished - Nov 8 2010
Externally publishedYes
Event26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States
Duration: Apr 30 2010May 2 2010

Publication series

NameIFMBE Proceedings
Volume32 IFMBE
ISSN (Print)1680-0737

Other

Other26th Southern Biomedical Engineering Conference, SBEC 2010
CountryUnited States
CityCollege Park, MD
Period4/30/105/2/10

Keywords

  • Cancer
  • Drug resistance
  • Ordinary differential equations

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Tomasetti, C., & Levy, D. (2010). Drug resistance always depends on the turnover rate. In 26th Southern Biomedical Engineering Conference SBEC 2010 (pp. 552-555). (IFMBE Proceedings; Vol. 32 IFMBE). https://doi.org/10.1007/978-3-642-14998-6_141