Drug resistance always depends on the turnover rate

C. Tomasetti; D. Levy

doi:10.1007/978-3-642-14998-6_141

Drug resistance always depends on the turnover rate

C. Tomasetti, D. Levy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations. A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate. In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.

Original language	English (US)
Title of host publication	26th Southern Biomedical Engineering Conference SBEC 2010
Pages	552-555
Number of pages	4
DOIs	https://doi.org/10.1007/978-3-642-14998-6_141
State	Published - 2010
Externally published	Yes
Event	26th Southern Biomedical Engineering Conference, SBEC 2010 - College Park, MD, United States Duration: Apr 30 2010 → May 2 2010

Publication series

Name	IFMBE Proceedings
Volume	32 IFMBE
ISSN (Print)	1680-0737

Other

Other	26th Southern Biomedical Engineering Conference, SBEC 2010
Country/Territory	United States
City	College Park, MD
Period	4/30/10 → 5/2/10

Keywords

Cancer
Drug resistance
Ordinary differential equations

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

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10.1007/978-3-642-14998-6_141

Cite this

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title = "Drug resistance always depends on the turnover rate",

abstract = "Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations. A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate. In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.",

keywords = "Cancer, Drug resistance, Ordinary differential equations",

author = "C. Tomasetti and D. Levy",

year = "2010",

doi = "10.1007/978-3-642-14998-6_141",

language = "English (US)",

isbn = "9783642149979",

series = "IFMBE Proceedings",

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TY - GEN

T1 - Drug resistance always depends on the turnover rate

AU - Tomasetti, C.

AU - Levy, D.

PY - 2010

Y1 - 2010

N2 - Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations. A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate. In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.

AB - Resistance to drugs is a fundamental problem in the treatment of many diseases. In this work we consider the problem of drug resistance in cancer, focusing on random genetic point mutations. A recent result obtained by Komarova is that for the case of a single drug treatment, the probability to have resistant mutants generated before the beginning of the treatment (and present, including their progeny, at some given time afterward) does not depend on the cancer turnover rate. This implies that the treatment success will not depend on such rate. In this paper we show that the number of such resistant mutants must depend on the turnover rate, which will also be the case for the success of the treatment.

KW - Cancer

KW - Drug resistance

KW - Ordinary differential equations

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U2 - 10.1007/978-3-642-14998-6_141

DO - 10.1007/978-3-642-14998-6_141

M3 - Conference contribution

AN - SCOPUS:78049292532

SN - 9783642149979

T3 - IFMBE Proceedings

SP - 552

EP - 555

BT - 26th Southern Biomedical Engineering Conference SBEC 2010

T2 - 26th Southern Biomedical Engineering Conference, SBEC 2010

Y2 - 30 April 2010 through 2 May 2010

ER -

Drug resistance always depends on the turnover rate

Abstract

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Keywords

ASJC Scopus subject areas

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