Drug infusions for the diagnosis and treatment of chronic pain.

David A. O'Gorman, Srinivasa N. Raja

Research output: Contribution to journalReview article

Abstract

Diagnostic infusion therapy has several advantages over other routes of drug administration in the management of chronic pain. Although systemic side effects may occur, the procedure is relatively noninvasive and is generally well tolerated by patients. Infusion techniques have a potential use in the blinded evaluation of a patient's response to a specific therapy, and thus may minimize placebo responses associated with the more invasive diagnostic nerve blocks. Infusion tests may be useful prognostic indicators of the potential efficacy of a class of oral drugs in a patient. This article reviews the scientific and clinical background behind the major classes of drugs used in diagnostic infusion testing, namely local anesthetics, opioids, and a-adrenergic blockers. Clinical application of these agents in the management of chronic pain also is outlined.

Original languageEnglish (US)
Pages (from-to)452-459
Number of pages8
JournalCurrent pain and headache reports
Volume6
Issue number6
DOIs
StatePublished - Dec 2002

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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