Drug-induced long QT syndrome in injection drug users receiving methadone

High frequency in hospitalized patients and risk factors

Georg B. Ehret, Cathy Voide, Marianne Gex-Fabry, Jocelyne Chabert, Dipen Shah, Barbara Broers, Valérie Piguet, Thierry Musset, Jean Michel Gaspoz, Arnaud Perrier, Pierre Dayer, Jules A. Desmeules

Research output: Contribution to journalArticle

Abstract

Background: Drug-induced long QT syndrome is a serious adverse drug reaction. Methadone prolongs the QT interval in vitro in a dose-dependent manner. In the inpatient setting, the frequency of QT interval prolongation with methadone treatment, its dose dependence, and the importance of cofactors such as drug-drug interactions remain unknown. Methods: We performed a systematic, retrospective study comparing active or former intravenous drug users receiving methadone and those not receiving methadone among all patients hospitalized over a 5-year period in a tertiary care hospital. A total of 167 patients receiving methadone fulfilled the inclusion criteria and were compared with a control group of 80 injection drug users not receiving methadone. In addition to methadone dose, 15 demographic, biological, and pharmacological variables were considered as potential risk factors for QT prolongation. Results: Among 167 methadone maintenance patients, the prevalence of QTc prolongation to 0.50 second1/2 or longer was 16.2% compared with 0% in 80 control subjects. Six patients (3.6%) in the methadone group presented torsades de pointes. QTc length was weakly but significantly associated with methadone daily dose (Spearman rank correlation coefficient, 0.20; P

Original languageEnglish (US)
Pages (from-to)1280-1287
Number of pages8
JournalArchives of Internal Medicine
Volume166
Issue number12
DOIs
StatePublished - Jun 26 2006

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Long QT Syndrome
Methadone
Drug Users
Injections
Pharmaceutical Preparations
Torsades de Pointes
Tertiary Healthcare
Nonparametric Statistics
Drug-Related Side Effects and Adverse Reactions
Drug Interactions
Tertiary Care Centers
Inpatients
Retrospective Studies
Demography
Pharmacology

ASJC Scopus subject areas

  • Internal Medicine

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Drug-induced long QT syndrome in injection drug users receiving methadone : High frequency in hospitalized patients and risk factors. / Ehret, Georg B.; Voide, Cathy; Gex-Fabry, Marianne; Chabert, Jocelyne; Shah, Dipen; Broers, Barbara; Piguet, Valérie; Musset, Thierry; Gaspoz, Jean Michel; Perrier, Arnaud; Dayer, Pierre; Desmeules, Jules A.

In: Archives of Internal Medicine, Vol. 166, No. 12, 26.06.2006, p. 1280-1287.

Research output: Contribution to journalArticle

Ehret, GB, Voide, C, Gex-Fabry, M, Chabert, J, Shah, D, Broers, B, Piguet, V, Musset, T, Gaspoz, JM, Perrier, A, Dayer, P & Desmeules, JA 2006, 'Drug-induced long QT syndrome in injection drug users receiving methadone: High frequency in hospitalized patients and risk factors', Archives of Internal Medicine, vol. 166, no. 12, pp. 1280-1287. https://doi.org/10.1001/archinte.166.12.1280
Ehret, Georg B. ; Voide, Cathy ; Gex-Fabry, Marianne ; Chabert, Jocelyne ; Shah, Dipen ; Broers, Barbara ; Piguet, Valérie ; Musset, Thierry ; Gaspoz, Jean Michel ; Perrier, Arnaud ; Dayer, Pierre ; Desmeules, Jules A. / Drug-induced long QT syndrome in injection drug users receiving methadone : High frequency in hospitalized patients and risk factors. In: Archives of Internal Medicine. 2006 ; Vol. 166, No. 12. pp. 1280-1287.
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