Drug-induced gynecomastia

Ari Eckman, Adrian S Dobs

Research output: Contribution to journalArticle

Abstract

Gynecomastia is caused by drugs in 10-25% of all cases. The pathophysiologic mechanism for some drugs includes exogenous estrogens exposure, medications that cause hypogonadism, anti-androgenic effects and hyperprolactinemia. This manuscript reviews common examples of drug-induced gynecomastia, discussing the mechanisms and possible treatments. Discontinuing the medication is always the best choice; however, if this is not possible, then testosterone replacement therapy may be needed for hypogonadism. When a man is euogonadal, a trial of the anti-estrogen, tamoxifen or an aromatase inhibitor may be an option.

Original languageEnglish (US)
Pages (from-to)691-702
Number of pages12
JournalExpert Opinion on Drug Safety
Volume7
Issue number6
DOIs
Publication statusPublished - Nov 2008

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Keywords

  • Breast
  • Drug-induced
  • Gynecomastia
  • Hypogonadism

ASJC Scopus subject areas

  • Pharmacology (medical)

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