Drug-Induced Dilutional Hyponatremia

Robert K. Novich; Crawford Chung; David S. Tatro; Arnold M. Moses; Myron Miller

doi:10.1056/NEJM197504102921518

Drug-Induced Dilutional Hyponatremia

Robert K. Novich, Crawford Chung, David S. Tatro, Arnold M. Moses, Myron Miller

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

To the Editor: I should like to take issue with the statement made by Moses and Miller (N Engl J Med 291:1234–1239, 1974) that the cardinal feature of water retention in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a urine osmolality that is hypertonic to plasma. This common misconception is pointed out by Schwartz and Bartter in their review of the disease (Bartter EC, Schwartz WB: The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:794, 1967). Here the authors state that it is not necessary for the urine to be hypertonic to the plasma.

Original language	English (US)
Pages (from-to)	810-811
Number of pages	2
Journal	New England Journal of Medicine
Volume	292
Issue number	15
DOIs	https://doi.org/10.1056/NEJM197504102921518
State	Published - Apr 10 1975
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Drug-Induced Dilutional Hyponatremia",

abstract = "To the Editor: I should like to take issue with the statement made by Moses and Miller (N Engl J Med 291:1234–1239, 1974) that the cardinal feature of water retention in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a urine osmolality that is hypertonic to plasma. This common misconception is pointed out by Schwartz and Bartter in their review of the disease (Bartter EC, Schwartz WB: The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:794, 1967). Here the authors state that it is not necessary for the urine to be hypertonic to the plasma.",

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T1 - Drug-Induced Dilutional Hyponatremia

AU - Novich, Robert K.

AU - Chung, Crawford

AU - Tatro, David S.

AU - Moses, Arnold M.

AU - Miller, Myron

PY - 1975/4/10

Y1 - 1975/4/10

N2 - To the Editor: I should like to take issue with the statement made by Moses and Miller (N Engl J Med 291:1234–1239, 1974) that the cardinal feature of water retention in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a urine osmolality that is hypertonic to plasma. This common misconception is pointed out by Schwartz and Bartter in their review of the disease (Bartter EC, Schwartz WB: The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:794, 1967). Here the authors state that it is not necessary for the urine to be hypertonic to the plasma.

AB - To the Editor: I should like to take issue with the statement made by Moses and Miller (N Engl J Med 291:1234–1239, 1974) that the cardinal feature of water retention in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a urine osmolality that is hypertonic to plasma. This common misconception is pointed out by Schwartz and Bartter in their review of the disease (Bartter EC, Schwartz WB: The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:794, 1967). Here the authors state that it is not necessary for the urine to be hypertonic to the plasma.

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Drug-Induced Dilutional Hyponatremia

Abstract

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