Drug eluting stents for malignant airway obstruction: A critical review of the literature

Wolfgang Hohenforst-Schmidt; Paul Zarogoulidis; Georgia Pitsiou; Bernd Linsmeier; Drosos Tsavlis; Ioannis Kioumis; Eleni Papadaki; Lutz Freitag; Theodora Tsiouda; J. Francis Turner; Robert Browning; Michael Simoff; Nikolaos Sachpekidis; Kosmas Tsakiridis; Bojan Zaric; Lonny Yarmus; Sofia Baka; Grigoris Stratakos; Harald Rittger

doi:10.7150/jca.13611

Drug eluting stents for malignant airway obstruction: A critical review of the literature

Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Georgia Pitsiou, Bernd Linsmeier, Drosos Tsavlis, Ioannis Kioumis, Eleni Papadaki, Lutz Freitag, Theodora Tsiouda, J. Francis Turner, Robert Browning, Michael Simoff, Nikolaos Sachpekidis, Kosmas Tsakiridis, Bojan Zaric, Lonny Yarmus, Sofia Baka, Grigoris Stratakos, Harald Rittger

School of Medicine

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Lung cancer being the most prevalent malignancy in men and the 3^rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement.

Original language	English (US)
Pages (from-to)	377-390
Number of pages	14
Journal	Journal of Cancer
Volume	7
Issue number	4
DOIs	https://doi.org/10.7150/jca.13611
State	Published - 2016

Keywords

Pharmacology
Stents

ASJC Scopus subject areas

Oncology

Access to Document

10.7150/jca.13611

Cite this

Hohenforst-Schmidt, W., Zarogoulidis, P., Pitsiou, G., Linsmeier, B., Tsavlis, D., Kioumis, I., Papadaki, E., Freitag, L., Tsiouda, T., Turner, J. F., Browning, R., Simoff, M., Sachpekidis, N., Tsakiridis, K., Zaric, B., Yarmus, L., Baka, S., Stratakos, G., & Rittger, H. (2016). Drug eluting stents for malignant airway obstruction: A critical review of the literature. Journal of Cancer, 7(4), 377-390. https://doi.org/10.7150/jca.13611

Hohenforst-Schmidt, W, Zarogoulidis, P, Pitsiou, G, Linsmeier, B, Tsavlis, D, Kioumis, I, Papadaki, E, Freitag, L, Tsiouda, T, Turner, JF, Browning, R, Simoff, M, Sachpekidis, N, Tsakiridis, K, Zaric, B, Yarmus, L, Baka, S, Stratakos, G & Rittger, H 2016, 'Drug eluting stents for malignant airway obstruction: A critical review of the literature', Journal of Cancer, vol. 7, no. 4, pp. 377-390. https://doi.org/10.7150/jca.13611

@article{63a2f375b5d245f49fd25d087fca45b2,

title = "Drug eluting stents for malignant airway obstruction: A critical review of the literature",

abstract = "Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement.",

keywords = "Pharmacology, Stents",

author = "Wolfgang Hohenforst-Schmidt and Paul Zarogoulidis and Georgia Pitsiou and Bernd Linsmeier and Drosos Tsavlis and Ioannis Kioumis and Eleni Papadaki and Lutz Freitag and Theodora Tsiouda and Turner, {J. Francis} and Robert Browning and Michael Simoff and Nikolaos Sachpekidis and Kosmas Tsakiridis and Bojan Zaric and Lonny Yarmus and Sofia Baka and Grigoris Stratakos and Harald Rittger",

note = "Publisher Copyright: {\textcopyright} Ivyspring International Publisher.",

year = "2016",

doi = "10.7150/jca.13611",

language = "English (US)",

volume = "7",

pages = "377--390",

journal = "Journal of Cancer",

issn = "1837-9664",

publisher = "Ivyspring International Publisher",

number = "4",

}

TY - JOUR

T1 - Drug eluting stents for malignant airway obstruction

T2 - A critical review of the literature

AU - Hohenforst-Schmidt, Wolfgang

AU - Zarogoulidis, Paul

AU - Pitsiou, Georgia

AU - Linsmeier, Bernd

AU - Tsavlis, Drosos

AU - Kioumis, Ioannis

AU - Papadaki, Eleni

AU - Freitag, Lutz

AU - Tsiouda, Theodora

AU - Turner, J. Francis

AU - Browning, Robert

AU - Simoff, Michael

AU - Sachpekidis, Nikolaos

AU - Tsakiridis, Kosmas

AU - Zaric, Bojan

AU - Yarmus, Lonny

AU - Baka, Sofia

AU - Stratakos, Grigoris

AU - Rittger, Harald

PY - 2016

Y1 - 2016

N2 - Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement.

AB - Lung cancer being the most prevalent malignancy in men and the 3rd most frequent in women is still associated with dismal prognosis due to advanced disease at the time of diagnosis. Novel targeted therapies are already on the market and several others are under investigation. However non-specific cytotoxic agents still remain the cornerstone of treatment for many patients. Central airways stenosis or obstruction may often complicate and decrease quality of life and survival of these patients. Interventional pulmonology modalities (mainly debulking and stent placement) can alleviate symptoms related to airways stenosis and improve the quality of life of patients. Mitomycin C and sirolimus have been observed to assist a successful stent placement by reducing granuloma tissue formation. Additionally, these drugs enhance the normal tissue ability against cancer cell infiltration. In this mini review we will concentrate on mitomycin C and sirolimus and their use in stent placement.

KW - Pharmacology

KW - Stents

UR - http://www.scopus.com/inward/record.url?scp=84971538925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84971538925&partnerID=8YFLogxK

U2 - 10.7150/jca.13611

DO - 10.7150/jca.13611

M3 - Review article

C2 - 26918052

AN - SCOPUS:84971538925

SN - 1837-9664

VL - 7

SP - 377

EP - 390

JO - Journal of Cancer

JF - Journal of Cancer

IS - 4

ER -

Drug eluting stents for malignant airway obstruction: A critical review of the literature

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this