Drug effect on blink rates in rhesus monkeys: Preliminary studies

C. N. Karson, R. A. Staub, J. E. Kleinman, R. J. Wyatt

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean ± SD blink rate slightly to 18.2 ± 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 ± 7.6 blinks/90 sec to 37 ± 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 ± 2.8 blinks/90 sec. to 41.9 ± 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalBiological psychiatry
Issue number3
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry


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