Drug effect on blink rates in rhesus monkeys: Preliminary studies

C. N. Karson, R. A. Staub, Joel Kleinman, R. J. Wyatt

Research output: Contribution to journalArticle

Abstract

Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean ± SD blink rate slightly to 18.2 ± 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 ± 7.6 blinks/90 sec to 37 ± 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 ± 2.8 blinks/90 sec. to 41.9 ± 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalBiological Psychiatry
Volume16
Issue number3
StatePublished - 1981
Externally publishedYes

Fingerprint

Pargyline
Blinking
Macaca mulatta
Phenethylamines
Apomorphine
Haloperidol
Pharmaceutical Preparations
Haplorhini
Therapeutics
Tardive Dyskinesia

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Karson, C. N., Staub, R. A., Kleinman, J., & Wyatt, R. J. (1981). Drug effect on blink rates in rhesus monkeys: Preliminary studies. Biological Psychiatry, 16(3), 249-254.

Drug effect on blink rates in rhesus monkeys : Preliminary studies. / Karson, C. N.; Staub, R. A.; Kleinman, Joel; Wyatt, R. J.

In: Biological Psychiatry, Vol. 16, No. 3, 1981, p. 249-254.

Research output: Contribution to journalArticle

Karson, CN, Staub, RA, Kleinman, J & Wyatt, RJ 1981, 'Drug effect on blink rates in rhesus monkeys: Preliminary studies', Biological Psychiatry, vol. 16, no. 3, pp. 249-254.
Karson, C. N. ; Staub, R. A. ; Kleinman, Joel ; Wyatt, R. J. / Drug effect on blink rates in rhesus monkeys : Preliminary studies. In: Biological Psychiatry. 1981 ; Vol. 16, No. 3. pp. 249-254.
@article{dbe84c7870034523bc9ba61d7c0fc5cf,
title = "Drug effect on blink rates in rhesus monkeys: Preliminary studies",
abstract = "Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean ± SD blink rate slightly to 18.2 ± 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 ± 7.6 blinks/90 sec to 37 ± 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 ± 2.8 blinks/90 sec. to 41.9 ± 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.",
author = "Karson, {C. N.} and Staub, {R. A.} and Joel Kleinman and Wyatt, {R. J.}",
year = "1981",
language = "English (US)",
volume = "16",
pages = "249--254",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Drug effect on blink rates in rhesus monkeys

T2 - Preliminary studies

AU - Karson, C. N.

AU - Staub, R. A.

AU - Kleinman, Joel

AU - Wyatt, R. J.

PY - 1981

Y1 - 1981

N2 - Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean ± SD blink rate slightly to 18.2 ± 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 ± 7.6 blinks/90 sec to 37 ± 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 ± 2.8 blinks/90 sec. to 41.9 ± 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

AB - Various drugs that alter central monoamine activity were given to monkeys to determine effects on blink rate. Chronic pargyline treatment raised the mean ± SD blink rate slightly to 18.2 ± 5.3 blinks/90 sec. When phenylethylamine was added to chronic pargyline treatment, blinks increased from a base line of 16.8 ± 7.6 blinks/90 sec to 37 ± 15 blinks/90 sec. Apomorphine (0.36 mg/kg) raised blinks from a base line of 12.2 ± 2.8 blinks/90 sec. to 41.9 ± 10.3 blinks/90 sec. and reversed a decrease in blinking caused by haloperidol. The neurochemical basis of blinking and implications for tardive dyskinesia are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0019412125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019412125&partnerID=8YFLogxK

M3 - Article

C2 - 7225488

AN - SCOPUS:0019412125

VL - 16

SP - 249

EP - 254

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 3

ER -