TY - JOUR
T1 - Drug Dosing during Intermittent Hemodialysis and Continuous Renal Replacement Therapy
T2 - Special Considerations in Pediatric Patients
AU - Veltri, Michael A.
AU - Neu, Alicia M.
AU - Fivush, Barbara A.
AU - Parekh, Rulan S.
AU - Furth, Susan L.
N1 - Funding Information:
We would like to thank Dr Gary Matzke for his thoughtful comments on an earlier version of this manuscript. Dr Susan L. Furth is supported by an award from the NIDDK K08 DK02586-01A1.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004
Y1 - 2004
N2 - Chronic renal failure is, fortunately, an unusual occurrence in children; however, many children with various underlying illnesses develop acute renal failure, and transiently require renal replacement therapy - peritoneal dialysis, intermittent hemodialysis (IHD), or continuous renal replacement therapy (CRRT). As children with acute and chronic renal failure often have multiple comorbid conditions requiring drug therapy, generalists, intensivists, nephrologists, and pharmacists need to be aware of the issues surrounding the management of drug therapy in pediatric patients undergoing renal replacement therapy. This article summarizes the pharmacokinetics and dosing of many drugs commonly prescribed for pediatric patients, and focuses on the management of drug therapy in pediatric patients undergoing IHD and CRRT in the intensive care unit setting. Peritoneal dialysis is not considered in this review. Finally, a summary table with recommended initial dosages for drugs commonly encountered in pediatric patients requiring IHD or CRRT is presented.
AB - Chronic renal failure is, fortunately, an unusual occurrence in children; however, many children with various underlying illnesses develop acute renal failure, and transiently require renal replacement therapy - peritoneal dialysis, intermittent hemodialysis (IHD), or continuous renal replacement therapy (CRRT). As children with acute and chronic renal failure often have multiple comorbid conditions requiring drug therapy, generalists, intensivists, nephrologists, and pharmacists need to be aware of the issues surrounding the management of drug therapy in pediatric patients undergoing renal replacement therapy. This article summarizes the pharmacokinetics and dosing of many drugs commonly prescribed for pediatric patients, and focuses on the management of drug therapy in pediatric patients undergoing IHD and CRRT in the intensive care unit setting. Peritoneal dialysis is not considered in this review. Finally, a summary table with recommended initial dosages for drugs commonly encountered in pediatric patients requiring IHD or CRRT is presented.
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U2 - 10.2165/00148581-200406010-00004
DO - 10.2165/00148581-200406010-00004
M3 - Review article
C2 - 14969569
AN - SCOPUS:1542287262
SN - 1174-5878
VL - 6
SP - 45
EP - 65
JO - Pediatric Drugs
JF - Pediatric Drugs
IS - 1
ER -