Drug Dosing during Intermittent Hemodialysis and Continuous Renal Replacement Therapy: Special Considerations in Pediatric Patients

Michael A. Veltri, Alicia M. Neu, Barbara A. Fivush, Rulan S. Parekh, Susan L. Furth

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic renal failure is, fortunately, an unusual occurrence in children; however, many children with various underlying illnesses develop acute renal failure, and transiently require renal replacement therapy - peritoneal dialysis, intermittent hemodialysis (IHD), or continuous renal replacement therapy (CRRT). As children with acute and chronic renal failure often have multiple comorbid conditions requiring drug therapy, generalists, intensivists, nephrologists, and pharmacists need to be aware of the issues surrounding the management of drug therapy in pediatric patients undergoing renal replacement therapy. This article summarizes the pharmacokinetics and dosing of many drugs commonly prescribed for pediatric patients, and focuses on the management of drug therapy in pediatric patients undergoing IHD and CRRT in the intensive care unit setting. Peritoneal dialysis is not considered in this review. Finally, a summary table with recommended initial dosages for drugs commonly encountered in pediatric patients requiring IHD or CRRT is presented.

Original languageEnglish (US)
Pages (from-to)45-65
Number of pages21
JournalPediatric Drugs
Volume6
Issue number1
DOIs
StatePublished - Mar 16 2004

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

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