Drug delivery to brain tumors

Research output: Contribution to journalReview articlepeer-review

Abstract

A prerequisite for the efficacy of any cancer drug is that it reaches the tumor in therapeutic concentrations. This is difficult to accomplish in most systemic solid tumors because of factors such as variable hypoxia, iptratumoral pressure gradients, and abnormal vasculature within the tumors. In brain cancer, the situation is complicated by the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier, which serve as physical and physiologic obstacles for delivery of drugs to the central nervous system. Many approaches to overcome, circumvent, disrupt, or manipulate the BBB to enhance delivery of drugs to brain tumors have been devised and are in active investigation. These approaches include high-dose intravenous chemotherapy, intra-arterial drug delivery, local drug delivery via implanted polymers or catheters, BBB disruption, and biochemical modulation of drugs.

Original languageEnglish (US)
Pages (from-to)235-241
Number of pages7
JournalCurrent neurology and neuroscience reports
Volume8
Issue number3
DOIs
StatePublished - May 2008

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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