Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres

Qingguo Xu, Jan T. Czemuszka

Research output: Contribution to journalConference articlepeer-review

Abstract

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume1063
StatePublished - Dec 1 2008
EventSolids at the Biological Interface - Boston, MA, United States
Duration: Nov 26 2007Nov 30 2007

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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