Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres

Qingguo Xu, Jan T. Czemuszka

Research output: Contribution to journalArticle

Abstract

Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalMaterials Research Society Symposium Proceedings
Volume1063
StatePublished - 2008
Externally publishedYes

Fingerprint

Microspheres
delivery
drugs
acids
Acids
Hydroxyapatite
Durapatite
Amoxicillin
antibiotics
infectious diseases
Pharmaceutical Preparations
sodium sulfates
Anionic surfactants
Focused ion beams
x ray spectroscopy
bones
Sodium dodecyl sulfate
Antibiotics
Encapsulation
oils

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres. / Xu, Qingguo; Czemuszka, Jan T.

In: Materials Research Society Symposium Proceedings, Vol. 1063, 2008, p. 33-38.

Research output: Contribution to journalArticle

@article{d42ad26b718b42dd8fca86f3accf6893,
title = "Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres",
abstract = "Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6{\%}. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.",
author = "Qingguo Xu and Czemuszka, {Jan T.}",
year = "2008",
language = "English (US)",
volume = "1063",
pages = "33--38",
journal = "Materials Research Society Symposium - Proceedings",
issn = "0272-9172",
publisher = "Materials Research Society",

}

TY - JOUR

T1 - Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres

AU - Xu, Qingguo

AU - Czemuszka, Jan T.

PY - 2008

Y1 - 2008

N2 - Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.

AB - Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.

UR - http://www.scopus.com/inward/record.url?scp=67649231455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649231455&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:67649231455

VL - 1063

SP - 33

EP - 38

JO - Materials Research Society Symposium - Proceedings

JF - Materials Research Society Symposium - Proceedings

SN - 0272-9172

ER -