Abstract
Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 33-38 |
| Number of pages | 6 |
| Journal | Materials Research Society Symposium Proceedings |
| Volume | 1063 |
| State | Published - 2008 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Mechanical Engineering
- Mechanics of Materials
- Materials Science(all)
- Condensed Matter Physics
Cite this
Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres. / Xu, Qingguo; Czemuszka, Jan T.
In: Materials Research Society Symposium Proceedings, Vol. 1063, 2008, p. 33-38.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Drug delivery systems based on hydroxyapaptite-coated poly(lactic-co- glycolic acid) microspheres
AU - Xu, Qingguo
AU - Czemuszka, Jan T.
PY - 2008
Y1 - 2008
N2 - Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.
AB - Negatively charged poly(lactic-co-glycolic acid) (PLGA) microspheres were prepared by the solid-in-oil-in-water (s/o/w) method using the anionic surfactant, sodium dodecyl sulfate (SDS), and a hydrophilic antibiotic (amoxicillin) was encapsulated with an encapsulation efficiency of 40.6%. A layer of hydroxyapatite (HA) was coated on these negatively charged PLGA microspheres by a dual constant composition method in 3-6 hours. The HA-coated PLGA microspheres (HPLG) had a core-shell structure and were characterized by scanning electron microscopy, focused ion beam microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction and Fourier transform infrared spectroscopy. Sustained release of amoxicillin from HPLG for at least 31 days was shown from in-vitro drug release experiments. A typical triphasic drug release profile had been observed for PLGA and HPLG microspheres. This device exhibited two desirable properties: the sustained release from PLGA and potential osteoconductivity from HA. Hence, it could have applications in delivering drugs to treat bone disorders or infections.
UR - http://www.scopus.com/inward/record.url?scp=67649231455&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649231455&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:67649231455
VL - 1063
SP - 33
EP - 38
JO - Materials Research Society Symposium - Proceedings
JF - Materials Research Society Symposium - Proceedings
SN - 0272-9172
ER -