Drug and neurotransmitter receptors in the brain

Research output: Contribution to journalArticle

Abstract

Biochemical investigation of receptors for neurotransmitters and drugs in the brain has been one of the most active areas of molecular neuroscience during the past decade. This work has permitted fundamental insights into how binding of neurotransmitters to their receptors excites or inhibits neuronal firing or changes cellular metabolism. The recognition of receptor subtypes has suggested subtle ways for neurotransmitters to modulate neuronal functioning. Finally, the ability to measure receptor sites in simple test tube systems and to distinguish readily between agonists and antagonists has provided useful probes for drug discovery programs.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalScience
Volume224
Issue number4644
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Drug and neurotransmitter receptors in the brain'. Together they form a unique fingerprint.

  • Cite this