Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

Vicki P. Losick, Lucy X. Morris, Donald T. Fox, Allan Spradling

Research output: Contribution to journalArticle

Abstract

The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special " state" based on novel " stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

Original languageEnglish (US)
Pages (from-to)159-171
Number of pages13
JournalDevelopmental Cell
Volume21
Issue number1
DOIs
StatePublished - Jul 19 2011
Externally publishedYes

Fingerprint

Stem Cell Niche
Stem cells
Drosophila
Stem Cells
Adult Stem Cells
Tissue
Cell Lineage
Diptera
Cell Differentiation
Health
Research
Genes

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Drosophila Stem Cell Niches : A Decade of Discovery Suggests a Unified View of Stem Cell Regulation. / Losick, Vicki P.; Morris, Lucy X.; Fox, Donald T.; Spradling, Allan.

In: Developmental Cell, Vol. 21, No. 1, 19.07.2011, p. 159-171.

Research output: Contribution to journalArticle

Losick, Vicki P. ; Morris, Lucy X. ; Fox, Donald T. ; Spradling, Allan. / Drosophila Stem Cell Niches : A Decade of Discovery Suggests a Unified View of Stem Cell Regulation. In: Developmental Cell. 2011 ; Vol. 21, No. 1. pp. 159-171.
@article{56d3cb97ed4a4cb6aa46449be33bbc17,
title = "Drosophila Stem Cell Niches: A Decade of Discovery Suggests a Unified View of Stem Cell Regulation",
abstract = "The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special {"} state{"} based on novel {"} stem cell genes{"} but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.",
author = "Losick, {Vicki P.} and Morris, {Lucy X.} and Fox, {Donald T.} and Allan Spradling",
year = "2011",
month = "7",
day = "19",
doi = "10.1016/j.devcel.2011.06.018",
language = "English (US)",
volume = "21",
pages = "159--171",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Drosophila Stem Cell Niches

T2 - A Decade of Discovery Suggests a Unified View of Stem Cell Regulation

AU - Losick, Vicki P.

AU - Morris, Lucy X.

AU - Fox, Donald T.

AU - Spradling, Allan

PY - 2011/7/19

Y1 - 2011/7/19

N2 - The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special " state" based on novel " stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

AB - The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special " state" based on novel " stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.

UR - http://www.scopus.com/inward/record.url?scp=79960237293&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960237293&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2011.06.018

DO - 10.1016/j.devcel.2011.06.018

M3 - Article

C2 - 21763616

AN - SCOPUS:79960237293

VL - 21

SP - 159

EP - 171

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 1

ER -