TY - JOUR
T1 - Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria
AU - Wang, Sibao
AU - Dos-Santos, André L.A.
AU - Huang, Wei
AU - Liu, Kun Connie
AU - Oshaghi, Mohammad Ali
AU - Wei, Ge
AU - Agre, Peter
AU - Jacobs-Lorena, Marcelo
N1 - Publisher Copyright:
© 2017, American Association for the Advancement of Science. All rights reserved.
PY - 2017/9/29
Y1 - 2017/9/29
N2 - The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have been shown to render mosquitoes resistant to the parasite, the challenge remains to effectively introduce such bacteria into mosquito populations. We describe a Serratia bacterium strain (AS1) isolated from Anopheles ovaries that stably colonizes the mosquito midgut, female ovaries, and male accessory glands and spreads rapidly throughout mosquito populations. Serratia AS1 was genetically engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit development of Plasmodium falciparum in mosquitoes.
AB - The huge burden of malaria in developing countries urgently demands the development of novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have been shown to render mosquitoes resistant to the parasite, the challenge remains to effectively introduce such bacteria into mosquito populations. We describe a Serratia bacterium strain (AS1) isolated from Anopheles ovaries that stably colonizes the mosquito midgut, female ovaries, and male accessory glands and spreads rapidly throughout mosquito populations. Serratia AS1 was genetically engineered for secretion of anti-Plasmodium effector proteins, and the recombinant strains inhibit development of Plasmodium falciparum in mosquitoes.
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U2 - 10.1126/science.aan5478
DO - 10.1126/science.aan5478
M3 - Article
C2 - 28963255
AN - SCOPUS:85030125023
SN - 0036-8075
VL - 357
SP - 1399
EP - 1402
JO - Science
JF - Science
IS - 6358
ER -