Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton; Robert P. Hirt; Joana C. Silva; Arthur L. Delcher; Michael Schatz; Qi Zhao; Jennifer R. Wortman; Shelby L. Bidwell; U. Cecilia M. Alsmark; Sébastien Besteiro; Thomas Sicheritz-Ponten; Christophe J. Noel; Joel B. Dacks; Peter G. Foster; Cedric Simillion; Yves Van De Peer; Diego Miranda-Saavedra; Geoffrey J. Barton; Gareth D. Westrop; Sylke Müller; Daniele Dessi; Pier Luigi Fiori; Qinghu Ren; Ian Paulsen; Hanbang Zhang; Felix D. Bastida-Corcuera; Augusto Simoes-Barbosa; Mark T. Brown; Richard D. Hayes; Mandira Mukherjee; Cheryl Y. Okumura; Rachel Schneider; Alias J. Smith; Stepanka Vanacova; Maria Villalvazo; Brian J. Haas; Mihaela Pertea; Tamara V. Feldblyum; Terry R. Utterback; Chung Li Shu; Kazutoyo Osoegawa; Pieter J. De Jong; Ivan Hrdy; Lenka Horvathova; Zuzana Zubacova; Pavel Dolezal; Shehre Banoo Malik; John M. Logsdon; Katrin Henze; Arti Gupta; Ching C. Wang; Rebecca L. Dunne; Jacqueline A. Upcroft; Peter Upcroft; Owen White; Steven L. Salzberg; Petrus Tang; Cheng Hsun Chiu; Ying Shiung Lee; T. Martin Embley; Graham H. Coombs; Jeremy C. Mottram; Jan Tachezy; Claire M. Fraser-Liggett; Patricia J. Johnson

doi:10.1126/science.1132894

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, Qi Zhao, Jennifer R. Wortman, Shelby L. Bidwell, U. Cecilia M. Alsmark, Sébastien Besteiro, Thomas Sicheritz-Ponten, Christophe J. Noel, Joel B. Dacks, Peter G. Foster, Cedric Simillion, Yves Van De Peer, Diego Miranda-Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke MüllerDaniele Dessi, Pier Luigi Fiori, Qinghu Ren, Ian Paulsen, Hanbang Zhang, Felix D. Bastida-Corcuera, Augusto Simoes-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Y. Okumura, Rachel Schneider, Alias J. Smith, Stepanka Vanacova, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry R. Utterback, Chung Li Shu, Kazutoyo Osoegawa, Pieter J. De Jong, Ivan Hrdy, Lenka Horvathova, Zuzana Zubacova, Pavel Dolezal, Shehre Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca L. Dunne, Jacqueline A. Upcroft, Peter Upcroft, Owen White, Steven L. Salzberg, Petrus Tang, Cheng Hsun Chiu, Ying Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser-Liggett, Patricia J. Johnson

Research output: Contribution to journal › Article › peer-review

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Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Original language	English (US)
Pages (from-to)	207-212
Number of pages	6
Journal	Science
Volume	315
Issue number	5809
DOIs	https://doi.org/10.1126/science.1132894
State	Published - Jan 12 2007
Externally published	Yes

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Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., Wortman, J. R., Bidwell, S. L., Alsmark, U. C. M., Besteiro, S., Sicheritz-Ponten, T., Noel, C. J., Dacks, J. B., Foster, P. G., Simillion, C., Van De Peer, Y., Miranda-Saavedra, D., Barton, G. J., Westrop, G. D., ... Johnson, P. J. (2007). Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315(5809), 207-212. https://doi.org/10.1126/science.1132894

Carlton, JM, Hirt, RP, Silva, JC, Delcher, AL, Schatz, M, Zhao, Q, Wortman, JR, Bidwell, SL, Alsmark, UCM, Besteiro, S, Sicheritz-Ponten, T, Noel, CJ, Dacks, JB, Foster, PG, Simillion, C, Van De Peer, Y, Miranda-Saavedra, D, Barton, GJ, Westrop, GD, Müller, S, Dessi, D, Fiori, PL, Ren, Q, Paulsen, I, Zhang, H, Bastida-Corcuera, FD, Simoes-Barbosa, A, Brown, MT, Hayes, RD, Mukherjee, M, Okumura, CY, Schneider, R, Smith, AJ, Vanacova, S, Villalvazo, M, Haas, BJ, Pertea, M, Feldblyum, TV, Utterback, TR, Shu, CL, Osoegawa, K, De Jong, PJ, Hrdy, I, Horvathova, L, Zubacova, Z, Dolezal, P, Malik, SB, Logsdon, JM, Henze, K, Gupta, A, Wang, CC, Dunne, RL, Upcroft, JA, Upcroft, P, White, O, Salzberg, SL, Tang, P, Chiu, CH, Lee, YS, Embley, TM, Coombs, GH, Mottram, JC, Tachezy, J, Fraser-Liggett, CM & Johnson, PJ 2007, 'Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis', Science, vol. 315, no. 5809, pp. 207-212. https://doi.org/10.1126/science.1132894

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title = "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis",

abstract = "We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.",

author = "Carlton, {Jane M.} and Hirt, {Robert P.} and Silva, {Joana C.} and Delcher, {Arthur L.} and Michael Schatz and Qi Zhao and Wortman, {Jennifer R.} and Bidwell, {Shelby L.} and Alsmark, {U. Cecilia M.} and S{\'e}bastien Besteiro and Thomas Sicheritz-Ponten and Noel, {Christophe J.} and Dacks, {Joel B.} and Foster, {Peter G.} and Cedric Simillion and {Van De Peer}, Yves and Diego Miranda-Saavedra and Barton, {Geoffrey J.} and Westrop, {Gareth D.} and Sylke M{\"u}ller and Daniele Dessi and Fiori, {Pier Luigi} and Qinghu Ren and Ian Paulsen and Hanbang Zhang and Bastida-Corcuera, {Felix D.} and Augusto Simoes-Barbosa and Brown, {Mark T.} and Hayes, {Richard D.} and Mandira Mukherjee and Okumura, {Cheryl Y.} and Rachel Schneider and Smith, {Alias J.} and Stepanka Vanacova and Maria Villalvazo and Haas, {Brian J.} and Mihaela Pertea and Feldblyum, {Tamara V.} and Utterback, {Terry R.} and Shu, {Chung Li} and Kazutoyo Osoegawa and {De Jong}, {Pieter J.} and Ivan Hrdy and Lenka Horvathova and Zuzana Zubacova and Pavel Dolezal and Malik, {Shehre Banoo} and Logsdon, {John M.} and Katrin Henze and Arti Gupta and Wang, {Ching C.} and Dunne, {Rebecca L.} and Upcroft, {Jacqueline A.} and Peter Upcroft and Owen White and Salzberg, {Steven L.} and Petrus Tang and Chiu, {Cheng Hsun} and Lee, {Ying Shiung} and Embley, {T. Martin} and Coombs, {Graham H.} and Mottram, {Jeremy C.} and Jan Tachezy and Fraser-Liggett, {Claire M.} and Johnson, {Patricia J.}",

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doi = "10.1126/science.1132894",

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T1 - Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

AU - Carlton, Jane M.

AU - Hirt, Robert P.

AU - Silva, Joana C.

AU - Delcher, Arthur L.

AU - Schatz, Michael

AU - Zhao, Qi

AU - Wortman, Jennifer R.

AU - Bidwell, Shelby L.

AU - Alsmark, U. Cecilia M.

AU - Besteiro, Sébastien

AU - Sicheritz-Ponten, Thomas

AU - Noel, Christophe J.

AU - Dacks, Joel B.

AU - Foster, Peter G.

AU - Simillion, Cedric

AU - Van De Peer, Yves

AU - Miranda-Saavedra, Diego

AU - Barton, Geoffrey J.

AU - Westrop, Gareth D.

AU - Müller, Sylke

AU - Dessi, Daniele

AU - Fiori, Pier Luigi

AU - Ren, Qinghu

AU - Paulsen, Ian

AU - Zhang, Hanbang

AU - Bastida-Corcuera, Felix D.

AU - Simoes-Barbosa, Augusto

AU - Brown, Mark T.

AU - Hayes, Richard D.

AU - Mukherjee, Mandira

AU - Okumura, Cheryl Y.

AU - Schneider, Rachel

AU - Smith, Alias J.

AU - Vanacova, Stepanka

AU - Villalvazo, Maria

AU - Haas, Brian J.

AU - Pertea, Mihaela

AU - Feldblyum, Tamara V.

AU - Utterback, Terry R.

AU - Shu, Chung Li

AU - Osoegawa, Kazutoyo

AU - De Jong, Pieter J.

AU - Hrdy, Ivan

AU - Horvathova, Lenka

AU - Zubacova, Zuzana

AU - Dolezal, Pavel

AU - Malik, Shehre Banoo

AU - Logsdon, John M.

AU - Henze, Katrin

AU - Gupta, Arti

AU - Wang, Ching C.

AU - Dunne, Rebecca L.

AU - Upcroft, Jacqueline A.

AU - Upcroft, Peter

AU - White, Owen

AU - Salzberg, Steven L.

AU - Tang, Petrus

AU - Chiu, Cheng Hsun

AU - Lee, Ying Shiung

AU - Embley, T. Martin

AU - Coombs, Graham H.

AU - Mottram, Jeremy C.

AU - Tachezy, Jan

AU - Fraser-Liggett, Claire M.

AU - Johnson, Patricia J.

PY - 2007/1/12

Y1 - 2007/1/12

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AB - We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

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SN - 0036-8075

VL - 315

SP - 207

EP - 212

JO - Science

JF - Science

IS - 5809

ER -

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Abstract

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