Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, Qi Zhao, Jennifer R. Wortman, Shelby L. Bidwell, U. Cecilia M Alsmark, Sébastien Besteiro, Thomas Sicheritz-Ponten, Christophe J. Noel, Joel B. Dacks, Peter G. Foster, Cedric Simillion, Yves Van De Peer, Diego Miranda-Saavedra, Geoffrey J. Barton, Gareth D. Westrop, Sylke Müller & 45 others Daniele Dessi, Pier Luigi Fiori, Qinghu Ren, Ian Paulsen, Hanbang Zhang, Felix D. Bastida-Corcuera, Augusto Simoes-Barbosa, Mark T. Brown, Richard D. Hayes, Mandira Mukherjee, Cheryl Y. Okumura, Rachel Schneider, Alias J. Smith, Stepanka Vanacova, Maria Villalvazo, Brian J. Haas, Mihaela Pertea, Tamara V. Feldblyum, Terry R. Utterback, Chung Li Shu, Kazutoyo Osoegawa, Pieter J. De Jong, Ivan Hrdy, Lenka Horvathova, Zuzana Zubacova, Pavel Dolezal, Shehre Banoo Malik, John M. Logsdon, Katrin Henze, Arti Gupta, Ching C. Wang, Rebecca L. Dunne, Jacqueline A. Upcroft, Peter Upcroft, Owen White, Steven L Salzberg, Petrus Tang, Cheng Hsun Chiu, Ying Shiung Lee, T. Martin Embley, Graham H. Coombs, Jeremy C. Mottram, Jan Tachezy, Claire M. Fraser-Liggett, Patricia J. Johnson

Research output: Contribution to journalArticle

Abstract

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ∼160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalScience
Volume315
Issue number5809
DOIs
StatePublished - Jan 12 2007
Externally publishedYes

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Trichomonas vaginalis
Genome
Horizontal Gene Transfer
DNA Transposable Elements
Gene Amplification
Metabolic Networks and Pathways
Phagocytosis
Organelles
Mitochondria
Parasites
Bacteria
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Carlton, J. M., Hirt, R. P., Silva, J. C., Delcher, A. L., Schatz, M., Zhao, Q., ... Johnson, P. J. (2007). Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science, 315(5809), 207-212. https://doi.org/10.1126/science.1132894

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. / Carlton, Jane M.; Hirt, Robert P.; Silva, Joana C.; Delcher, Arthur L.; Schatz, Michael; Zhao, Qi; Wortman, Jennifer R.; Bidwell, Shelby L.; Alsmark, U. Cecilia M; Besteiro, Sébastien; Sicheritz-Ponten, Thomas; Noel, Christophe J.; Dacks, Joel B.; Foster, Peter G.; Simillion, Cedric; Van De Peer, Yves; Miranda-Saavedra, Diego; Barton, Geoffrey J.; Westrop, Gareth D.; Müller, Sylke; Dessi, Daniele; Fiori, Pier Luigi; Ren, Qinghu; Paulsen, Ian; Zhang, Hanbang; Bastida-Corcuera, Felix D.; Simoes-Barbosa, Augusto; Brown, Mark T.; Hayes, Richard D.; Mukherjee, Mandira; Okumura, Cheryl Y.; Schneider, Rachel; Smith, Alias J.; Vanacova, Stepanka; Villalvazo, Maria; Haas, Brian J.; Pertea, Mihaela; Feldblyum, Tamara V.; Utterback, Terry R.; Shu, Chung Li; Osoegawa, Kazutoyo; De Jong, Pieter J.; Hrdy, Ivan; Horvathova, Lenka; Zubacova, Zuzana; Dolezal, Pavel; Malik, Shehre Banoo; Logsdon, John M.; Henze, Katrin; Gupta, Arti; Wang, Ching C.; Dunne, Rebecca L.; Upcroft, Jacqueline A.; Upcroft, Peter; White, Owen; Salzberg, Steven L; Tang, Petrus; Chiu, Cheng Hsun; Lee, Ying Shiung; Embley, T. Martin; Coombs, Graham H.; Mottram, Jeremy C.; Tachezy, Jan; Fraser-Liggett, Claire M.; Johnson, Patricia J.

In: Science, Vol. 315, No. 5809, 12.01.2007, p. 207-212.

Research output: Contribution to journalArticle

Carlton, JM, Hirt, RP, Silva, JC, Delcher, AL, Schatz, M, Zhao, Q, Wortman, JR, Bidwell, SL, Alsmark, UCM, Besteiro, S, Sicheritz-Ponten, T, Noel, CJ, Dacks, JB, Foster, PG, Simillion, C, Van De Peer, Y, Miranda-Saavedra, D, Barton, GJ, Westrop, GD, Müller, S, Dessi, D, Fiori, PL, Ren, Q, Paulsen, I, Zhang, H, Bastida-Corcuera, FD, Simoes-Barbosa, A, Brown, MT, Hayes, RD, Mukherjee, M, Okumura, CY, Schneider, R, Smith, AJ, Vanacova, S, Villalvazo, M, Haas, BJ, Pertea, M, Feldblyum, TV, Utterback, TR, Shu, CL, Osoegawa, K, De Jong, PJ, Hrdy, I, Horvathova, L, Zubacova, Z, Dolezal, P, Malik, SB, Logsdon, JM, Henze, K, Gupta, A, Wang, CC, Dunne, RL, Upcroft, JA, Upcroft, P, White, O, Salzberg, SL, Tang, P, Chiu, CH, Lee, YS, Embley, TM, Coombs, GH, Mottram, JC, Tachezy, J, Fraser-Liggett, CM & Johnson, PJ 2007, 'Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis', Science, vol. 315, no. 5809, pp. 207-212. https://doi.org/10.1126/science.1132894
Carlton JM, Hirt RP, Silva JC, Delcher AL, Schatz M, Zhao Q et al. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12;315(5809):207-212. https://doi.org/10.1126/science.1132894
Carlton, Jane M. ; Hirt, Robert P. ; Silva, Joana C. ; Delcher, Arthur L. ; Schatz, Michael ; Zhao, Qi ; Wortman, Jennifer R. ; Bidwell, Shelby L. ; Alsmark, U. Cecilia M ; Besteiro, Sébastien ; Sicheritz-Ponten, Thomas ; Noel, Christophe J. ; Dacks, Joel B. ; Foster, Peter G. ; Simillion, Cedric ; Van De Peer, Yves ; Miranda-Saavedra, Diego ; Barton, Geoffrey J. ; Westrop, Gareth D. ; Müller, Sylke ; Dessi, Daniele ; Fiori, Pier Luigi ; Ren, Qinghu ; Paulsen, Ian ; Zhang, Hanbang ; Bastida-Corcuera, Felix D. ; Simoes-Barbosa, Augusto ; Brown, Mark T. ; Hayes, Richard D. ; Mukherjee, Mandira ; Okumura, Cheryl Y. ; Schneider, Rachel ; Smith, Alias J. ; Vanacova, Stepanka ; Villalvazo, Maria ; Haas, Brian J. ; Pertea, Mihaela ; Feldblyum, Tamara V. ; Utterback, Terry R. ; Shu, Chung Li ; Osoegawa, Kazutoyo ; De Jong, Pieter J. ; Hrdy, Ivan ; Horvathova, Lenka ; Zubacova, Zuzana ; Dolezal, Pavel ; Malik, Shehre Banoo ; Logsdon, John M. ; Henze, Katrin ; Gupta, Arti ; Wang, Ching C. ; Dunne, Rebecca L. ; Upcroft, Jacqueline A. ; Upcroft, Peter ; White, Owen ; Salzberg, Steven L ; Tang, Petrus ; Chiu, Cheng Hsun ; Lee, Ying Shiung ; Embley, T. Martin ; Coombs, Graham H. ; Mottram, Jeremy C. ; Tachezy, Jan ; Fraser-Liggett, Claire M. ; Johnson, Patricia J. / Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. In: Science. 2007 ; Vol. 315, No. 5809. pp. 207-212.
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AU - Carlton, Jane M.

AU - Hirt, Robert P.

AU - Silva, Joana C.

AU - Delcher, Arthur L.

AU - Schatz, Michael

AU - Zhao, Qi

AU - Wortman, Jennifer R.

AU - Bidwell, Shelby L.

AU - Alsmark, U. Cecilia M

AU - Besteiro, Sébastien

AU - Sicheritz-Ponten, Thomas

AU - Noel, Christophe J.

AU - Dacks, Joel B.

AU - Foster, Peter G.

AU - Simillion, Cedric

AU - Van De Peer, Yves

AU - Miranda-Saavedra, Diego

AU - Barton, Geoffrey J.

AU - Westrop, Gareth D.

AU - Müller, Sylke

AU - Dessi, Daniele

AU - Fiori, Pier Luigi

AU - Ren, Qinghu

AU - Paulsen, Ian

AU - Zhang, Hanbang

AU - Bastida-Corcuera, Felix D.

AU - Simoes-Barbosa, Augusto

AU - Brown, Mark T.

AU - Hayes, Richard D.

AU - Mukherjee, Mandira

AU - Okumura, Cheryl Y.

AU - Schneider, Rachel

AU - Smith, Alias J.

AU - Vanacova, Stepanka

AU - Villalvazo, Maria

AU - Haas, Brian J.

AU - Pertea, Mihaela

AU - Feldblyum, Tamara V.

AU - Utterback, Terry R.

AU - Shu, Chung Li

AU - Osoegawa, Kazutoyo

AU - De Jong, Pieter J.

AU - Hrdy, Ivan

AU - Horvathova, Lenka

AU - Zubacova, Zuzana

AU - Dolezal, Pavel

AU - Malik, Shehre Banoo

AU - Logsdon, John M.

AU - Henze, Katrin

AU - Gupta, Arti

AU - Wang, Ching C.

AU - Dunne, Rebecca L.

AU - Upcroft, Jacqueline A.

AU - Upcroft, Peter

AU - White, Owen

AU - Salzberg, Steven L

AU - Tang, Petrus

AU - Chiu, Cheng Hsun

AU - Lee, Ying Shiung

AU - Embley, T. Martin

AU - Coombs, Graham H.

AU - Mottram, Jeremy C.

AU - Tachezy, Jan

AU - Fraser-Liggett, Claire M.

AU - Johnson, Patricia J.

PY - 2007/1/12

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