DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo

Michael A. Chattergoon, Karuppiah Muthumani, Yutaka Tamura, Mathura Ramanathan, Jason P. Shames, Vera Saulino, Tara M. Robinson, Luis J. Montaner, David B. Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Non-homeostatic tissue apoptosis in vivo has been shown to induce inflammatory responses and facilitate the cross-presentation of proteins within apoptotic bodies. We hypothesize that in the presence of foreign antigens, the apoptotic-inflammatory process improves immune priming; further, molecules that trigger apoptosis may be adapted for use as immune adjuvants. One very attractive molecule in this context is the tumor necrosis factor receptor (TNFR) family molecule DR5/TRAIL-receptor 2. We show a significant improvement in CD8+ T-cell mediated vaccine immunity with the use of death receptor-5 (DR5) as an immune adjuvant, a property that is correlated with the activation of caspases-8 (casp8) and dependent on its ability to induce apoptosis in vivo.

Original languageEnglish (US)
Pages (from-to)419-426
Number of pages8
JournalMolecular Therapy
Volume16
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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