DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families

Rhonda R. Voskuhl, Alisa M. Goldstein, Toni Simonis, Richard J. Davey, Henry F. McFarland

Research output: Contribution to journalArticlepeer-review

Abstract

Although the human leukocyte antigen DR2/DQw1 allele has been associated with multiple sclerosis, studies of DR2/DQw1 inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in 'high-incidence' families, defined as families with more than 50% of siblings affected. DR2/DQw1 allele frequencies were significantly increased, particularly in mothers and affected siblings (p <0.0001). The transmission of DR2/DQw1 from both parents was more frequent in affected offspring (p = 0.005). While evidence for segregation of disease with a particular parental allele was lacking in most families, the frequency of haplotype sharing was higher in affected sib pairs (p <0.01).

Original languageEnglish (US)
Pages (from-to)804-807
Number of pages4
JournalAnnals of Neurology
Volume39
Issue number6
DOIs
StatePublished - Jun 1996
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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