DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma

Geng Zhang, Aaron Schetter, Peijun He, Naotake Funamizu, Jochen Gaedcke, B. Michael Ghadimi, Thomas Ried, Raffit Hassan, Harris G. Yfantis, Dong H. Lee, Curtis Lacy, Anirban Maitra, Nader Hanna, H. Richard Alexander, S. Perwez Hussain

Research output: Contribution to journalArticlepeer-review

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. To identify biologically relevant genes with prognostic and therapeutic significance in PDAC, we first performed the microarray gene-expression profiling in 45 matching pairs of tumor and adjacent non-tumor tissues from resected PDAC cases. We identified 36 genes that were associated with patient outcome and also differentially expressed in tumors as compared with adjacent non-tumor tissues in microarray analysis. Further evaluation in an independent validation cohort (N = 27) confirmed that DPEP1 (dipeptidase 1) expression was decreased (T: N ratio ~0.1, P

Original languageEnglish (US)
Article numbere31507
JournalPLoS One
Volume7
Issue number2
DOIs
StatePublished - Feb 20 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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