DPC4 gene in various tumor types

Mieke Schutte, Ralph H. Hruban, Lora Hedrick, Kathleen R. Cho, Gyongyi Molnar Nadasdy, Craig L. Weinstein, G. Steven Bova, William B. Isaacs, Paul Cairns, Homaira Nawroz, David Sidransky, Robert A. Casero, Paul S. Meltzer, Stephan A. Hahn, Scott E. Kern

Research output: Contribution to journalArticlepeer-review

Abstract

We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21.1 and found that both alleles of DPC4 were inactivated in nearly one- half of the pancreatic carcinomas. Here, we analyzed 338 tumors, originating from 12 distinct anatomic sites, for alterations in the DPC4 gene. Sixty- four specimens were selected for the presence of the allelic loss of 18q and were further analyzed for DPC4 sequence alterations. An alteration of the DPC4 gene sequence was identified in one of eight breast carcinomas and one of eight ovarian carcinomas. These results indicate that whereas DPC4 inactivation is prevalent in pancreatic carcinoma (48%), it is distinctly uncommon (<10%) in the other tumor types examined. The tissue restriction of alterations in DPC4, as in many other tumor-suppressor genes, emphasizes the complexity of rate-limiting checkpoints in human tumorigenesis.

Original languageEnglish (US)
Pages (from-to)2527-2530
Number of pages4
JournalCancer Research
Volume56
Issue number11
StatePublished - Jun 1 1996

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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