DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

Stephan A. Hahn, Mieke Schutte, A. T.M. Shamsul Hoque, Christopher A. Moskaluk, Luis T. Da Costa, Ester Rozenblum, Craig L. Weinstein, Aryeh Fischer, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern

Research output: Contribution to journalArticlepeer-review

Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4, a gene similar in sequence to a Drosophila melanogaster gene (Mad) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

Original languageEnglish (US)
Pages (from-to)350-353
Number of pages4
JournalScience
Volume271
Issue number5247
DOIs
StatePublished - Jan 19 1996
Externally publishedYes

ASJC Scopus subject areas

  • General

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