TY - JOUR
T1 - Doxycycline for Travelers’ Diarrhea
T2 - Risks and Benefits
AU - Guerrant, Richard L.
AU - Hughes, James M.
AU - Sack, David A.
PY - 1978/12/21
Y1 - 1978/12/21
N2 - To the Editor: We compliment Sack and his colleagues on a well designed investigation of the efficacy of prophylactic doxycycline in the prevention of travelers’ diarrhea, as reported in the April 6 issue of the Journal, but we are concerned about generalizing from 18 patients treated with doxycycline. The basis for our concern is that such a small series does not exclude the potential hazards of giving the drug to large numbers of travelers who may wish to take prophylactic antibiotics. Although doxycycline may be unique since it is excreted into the small bowel, the effect of another prophylactic.
AB - To the Editor: We compliment Sack and his colleagues on a well designed investigation of the efficacy of prophylactic doxycycline in the prevention of travelers’ diarrhea, as reported in the April 6 issue of the Journal, but we are concerned about generalizing from 18 patients treated with doxycycline. The basis for our concern is that such a small series does not exclude the potential hazards of giving the drug to large numbers of travelers who may wish to take prophylactic antibiotics. Although doxycycline may be unique since it is excreted into the small bowel, the effect of another prophylactic.
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U2 - 10.1056/NEJM197812212992511
DO - 10.1056/NEJM197812212992511
M3 - Letter
C2 - 362208
AN - SCOPUS:0018197757
SN - 0028-4793
VL - 299
SP - 1412
EP - 1413
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 25
ER -