Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

H. G. Keizer; H. M. Pinedo; G. J. Schuurhuis; H. Joenje

doi:10.1016/0163-7258(90)90088-J

Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity

H. G. Keizer, H. M. Pinedo, G. J. Schuurhuis, H. Joenje

Research output: Contribution to journal › Article › peer-review

Abstract

The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.

Original language	English (US)
Pages (from-to)	219-231
Number of pages	13
Journal	Pharmacology and Therapeutics
Volume	47
Issue number	2
DOIs	https://doi.org/10.1016/0163-7258(90)90088-J
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology

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abstract = "The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.",

author = "Keizer, {H. G.} and Pinedo, {H. M.} and Schuurhuis, {G. J.} and H. Joenje",

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