Doxorubicin (adriamycin)

A critical review of free radical-dependent mechanisms of cytotoxicity

H. G. Keizer, H. M. Pinedo, G. J. Schuurhuis, H. Joenje

Research output: Contribution to journalArticle

Abstract

The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.

Original languageEnglish (US)
Pages (from-to)219-231
Number of pages13
JournalPharmacology and Therapeutics
Volume47
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Doxorubicin
Free Radicals
Tumor Cell Line
Antineoplastic Agents

ASJC Scopus subject areas

  • Pharmacology

Cite this

Doxorubicin (adriamycin) : A critical review of free radical-dependent mechanisms of cytotoxicity. / Keizer, H. G.; Pinedo, H. M.; Schuurhuis, G. J.; Joenje, H.

In: Pharmacology and Therapeutics, Vol. 47, No. 2, 1990, p. 219-231.

Research output: Contribution to journalArticle

Keizer, H. G. ; Pinedo, H. M. ; Schuurhuis, G. J. ; Joenje, H. / Doxorubicin (adriamycin) : A critical review of free radical-dependent mechanisms of cytotoxicity. In: Pharmacology and Therapeutics. 1990 ; Vol. 47, No. 2. pp. 219-231.
@article{51510e9c94d247409e0df2dc83883900,
title = "Doxorubicin (adriamycin): A critical review of free radical-dependent mechanisms of cytotoxicity",
abstract = "The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.",
author = "Keizer, {H. G.} and Pinedo, {H. M.} and Schuurhuis, {G. J.} and H. Joenje",
year = "1990",
doi = "10.1016/0163-7258(90)90088-J",
language = "English (US)",
volume = "47",
pages = "219--231",
journal = "Pharmacology and Therapeutics",
issn = "0163-7258",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Doxorubicin (adriamycin)

T2 - A critical review of free radical-dependent mechanisms of cytotoxicity

AU - Keizer, H. G.

AU - Pinedo, H. M.

AU - Schuurhuis, G. J.

AU - Joenje, H.

PY - 1990

Y1 - 1990

N2 - The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.

AB - The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.

UR - http://www.scopus.com/inward/record.url?scp=0025283897&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025283897&partnerID=8YFLogxK

U2 - 10.1016/0163-7258(90)90088-J

DO - 10.1016/0163-7258(90)90088-J

M3 - Article

VL - 47

SP - 219

EP - 231

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

SN - 0163-7258

IS - 2

ER -