Abstract
The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 219-231 |
| Number of pages | 13 |
| Journal | Pharmacology and Therapeutics |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1990 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Doxorubicin (adriamycin) : A critical review of free radical-dependent mechanisms of cytotoxicity. / Keizer, H. G.; Pinedo, H. M.; Schuurhuis, G. J.; Joenje, H.
In: Pharmacology and Therapeutics, Vol. 47, No. 2, 1990, p. 219-231.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Doxorubicin (adriamycin)
T2 - A critical review of free radical-dependent mechanisms of cytotoxicity
AU - Keizer, H. G.
AU - Pinedo, H. M.
AU - Schuurhuis, G. J.
AU - Joenje, H.
PY - 1990
Y1 - 1990
N2 - The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.
AB - The antineoplastic drug doxorubicin is capable of generating a variety of free radical species in subcellular systems and this capacity has been considered critical for its antitumor action. However, for most tumor cell lines this mechanism of cytotoxicity does not appear to play a major role. Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.
UR - http://www.scopus.com/inward/record.url?scp=0025283897&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025283897&partnerID=8YFLogxK
U2 - 10.1016/0163-7258(90)90088-J
DO - 10.1016/0163-7258(90)90088-J
M3 - Article
VL - 47
SP - 219
EP - 231
JO - Pharmacology and Therapeutics
JF - Pharmacology and Therapeutics
SN - 0163-7258
IS - 2
ER -