Down syndrome and Alzheimer's disease: Common pathways, common goals

Dean Hartley, Thomas Blumenthal, Maria Carrillo, Gilbert DiPaolo, Lucille Esralew, Katheleen Gardiner, Ann Charlotte Granholm, Khalid Iqbal, Michael Krams, Cynthia Lemere, Ira Lott, William Mobley, Seth Ness, Ralph Nixon, Huntington Potter, Roger Reeves, Marwan Sabbagh, Wayne Silverman, Benjamin Tycko, Michelle WhittenThomas Wisniewski

Research output: Contribution to journalArticle

Abstract

In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop Alzheimer's disease (AD) pathology starting in their 30s. With the current lifespan being 55 to 60 years, approximately 70% will develop dementia, and if their life expectancy continues to increase, the number of individuals developing AD will concomitantly increase. Pathogenic and mechanistic links between DS and Alzheimer's prompted the Alzheimer's Association to partner with the Linda Crnic Institute for Down Syndrome and the Global Down Syndrome Foundation at a workshop of AD and DS experts to discuss similarities and differences, challenges, and future directions for this field. The workshop articulated a set of research priorities: (1) target identification and drug development, (2) clinical and pathological staging, (3) cognitive assessment and clinical trials, and (4) partnerships and collaborations with the ultimate goal to deliver effective disease-modifying treatments.

Original languageEnglish (US)
Pages (from-to)700-709
Number of pages10
JournalAlzheimer's and Dementia
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • ADNI
  • Alzheimer's disease
  • Amyloid precursor protein
  • Animal models
  • Beta-amyloid
  • Biomarkers
  • Clinical trials
  • Cognitive assessment
  • DS-Connect
  • Dementia
  • Down syndrome
  • Drug discovery
  • Neuroimaging
  • Neuroinflammation
  • Tau
  • Trisomy 21
  • Ts65Dn
  • Workshop

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A. C., Iqbal, K., Krams, M., Lemere, C., Lott, I., Mobley, W., Ness, S., Nixon, R., Potter, H., Reeves, R., Sabbagh, M., Silverman, W., Tycko, B., ... Wisniewski, T. (2015). Down syndrome and Alzheimer's disease: Common pathways, common goals. Alzheimer's and Dementia, 11(6), 700-709. https://doi.org/10.1016/j.jalz.2014.10.007