Double‐Blind Evaluation of Plasmapheresis in Schizophrenic Patients: A Pilot Study

S. Charles Schulz; Daniel P. van Kammen; Robert Waters; Harvey G. Klein; James E. Balow; William E. Bunney

doi:10.1111/j.1525-1594.1983.tb04203.x

Double‐Blind Evaluation of Plasmapheresis in Schizophrenic Patients: A Pilot Study

S. Charles Schulz, Daniel P. van Kammen, Robert Waters, Harvey G. Klein, James E. Balow, William E. Bunney

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Abstract: Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double‐blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10) in the study fulfilled Research Diagnostic Criteria for schizophrenia and were randomly assigned to either sham or active plasmapheresis. They were blindly assessed by staff psychiatrists and nurses. Evaluation of the behavioral ratings revealed no significant decrease in psychosis for either the active or sham group. Also, no individual responding patient was identified. This finding complements our group's early negative results of a hemodialysis experiment and casts doubt on a simple autoimmune hypothesis of schizophrenia.

Original language	English (US)
Pages (from-to)	317-321
Number of pages	5
Journal	Artificial Organs
Volume	7
Issue number	3
DOIs	https://doi.org/10.1111/j.1525-1594.1983.tb04203.x
State	Published - 1983
Externally published	Yes

Keywords

Autoimmune disease
Hemodialysis
Plasmapheresis
Schizophrenia

ASJC Scopus subject areas

Medicine (miscellaneous)
Bioengineering
Biomaterials
Biomedical Engineering

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10.1111/j.1525-1594.1983.tb04203.x

Cite this

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title = "Double‐Blind Evaluation of Plasmapheresis in Schizophrenic Patients: A Pilot Study",

abstract = "Abstract: Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double‐blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10) in the study fulfilled Research Diagnostic Criteria for schizophrenia and were randomly assigned to either sham or active plasmapheresis. They were blindly assessed by staff psychiatrists and nurses. Evaluation of the behavioral ratings revealed no significant decrease in psychosis for either the active or sham group. Also, no individual responding patient was identified. This finding complements our group's early negative results of a hemodialysis experiment and casts doubt on a simple autoimmune hypothesis of schizophrenia.",

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T2 - A Pilot Study

AU - Schulz, S. Charles

AU - van Kammen, Daniel P.

AU - Waters, Robert

AU - Klein, Harvey G.

AU - Balow, James E.

AU - Bunney, William E.

PY - 1983

Y1 - 1983

N2 - Abstract: Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double‐blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10) in the study fulfilled Research Diagnostic Criteria for schizophrenia and were randomly assigned to either sham or active plasmapheresis. They were blindly assessed by staff psychiatrists and nurses. Evaluation of the behavioral ratings revealed no significant decrease in psychosis for either the active or sham group. Also, no individual responding patient was identified. This finding complements our group's early negative results of a hemodialysis experiment and casts doubt on a simple autoimmune hypothesis of schizophrenia.

AB - Abstract: Interest in the effects and possible mechanisms of hemodialysis on schizophrenic patients has led to a double‐blind evaluation of the effects of plasmapheresis on symptoms of schizophrenia. Also, plasmapheresis was felt to be an invaluable tool for investigating the autoimmune theory of schizophrenia. Patients (n = 10) in the study fulfilled Research Diagnostic Criteria for schizophrenia and were randomly assigned to either sham or active plasmapheresis. They were blindly assessed by staff psychiatrists and nurses. Evaluation of the behavioral ratings revealed no significant decrease in psychosis for either the active or sham group. Also, no individual responding patient was identified. This finding complements our group's early negative results of a hemodialysis experiment and casts doubt on a simple autoimmune hypothesis of schizophrenia.

KW - Autoimmune disease

KW - Hemodialysis

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KW - Schizophrenia

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Double‐Blind Evaluation of Plasmapheresis in Schizophrenic Patients: A Pilot Study

Abstract

Keywords

ASJC Scopus subject areas

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