Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic

Karen A. Wendel, Anne Marie Rompalo, Emily J. Erbelding, T. H. Chang, John F. Alderete

Research output: Contribution to journalArticle

Abstract

Trichomonas vaginalis (TV) can be infected with double-stranded RNA (dsRNA) viruses that may have important implications for trichomonal virulence and disease pathogenesis. A cross-sectional study was conducted in a sexually transmitted diseases clinic to determine the prevalence and clinical significance of dsRNA viral infection of TV infecting men and women. Overall, dsRNA virus was present in 21 (75%) of 28 TV isolates (95% confidence interval [CI], 55%-89%). dsRNA viral infection of TV was not associated with the presence of discharge, dysuria, genital pruritus, or genital irritation or odor. However, patients with virus-positive isolates were significantly older than patients with virus-negative isolates (median age, 38 vs. 23 years; P = .003), and virus-positive isolates were more prevalent among women (19 [86%] of 22 isolates; 95% CI, 65%-97%) than among men (2 [33%] of 6 isolates; P = .02). The age and sex specificity of virus-positive isolates may aid in understanding the differences in chronicity and clinical presentation of TV in men and women.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalJournal of Infectious Diseases
Volume186
Issue number4
DOIs
StatePublished - Aug 15 2002

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Trichomonas vaginalis
Double-Stranded RNA
Virus Diseases
Sexually Transmitted Diseases
Viruses
RNA Viruses
Confidence Intervals
Dysuria
Pruritus
Virulence
Cross-Sectional Studies

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic. / Wendel, Karen A.; Rompalo, Anne Marie; Erbelding, Emily J.; Chang, T. H.; Alderete, John F.

In: Journal of Infectious Diseases, Vol. 186, No. 4, 15.08.2002, p. 558-561.

Research output: Contribution to journalArticle

Wendel, Karen A. ; Rompalo, Anne Marie ; Erbelding, Emily J. ; Chang, T. H. ; Alderete, John F. / Double-stranded RNA viral infection of Trichomonas vaginalis infecting patients attending a sexually transmitted diseases clinic. In: Journal of Infectious Diseases. 2002 ; Vol. 186, No. 4. pp. 558-561.
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