Double-quantum surface-coil NMR studies of sodium and potassium in the rat brain

R. C. Lyon, James J Pekar, C. T W Moonen, A. C. McLaughlin

Research output: Contribution to journalArticle

Abstract

Double-quantum filtered and conventional single-pulse sodium and potassium NMR spectra were obtained from in situ rat brain at 7.0 T, using a surface coil. In contrast to the ca. 14% decrease observed in single-pulse sodium NMR spectra upon death, increases as large as ca. 800% were observed in double-quantum filtered sodium spectra. Conversely, a ca. 26% increase was observed in single-pulse potassium spectra upon death, while double-quantum filtered potassium spectra decreased below the noise level, for the shortest preparation time used. The decay rate of double-quantum sodium coherence in the in situ rat brain after death was dependent upon the double-quantum preparation time: this behavior results from the nonuniformity of the brain, and may be related to physiological compartmentalization. The potential application to sodium NMR imaging of cerebral functionality is briefly discussed.

Original languageEnglish (US)
Pages (from-to)80-92
Number of pages13
JournalMagnetic Resonance in Medicine
Volume18
Issue number1
StatePublished - 1991
Externally publishedYes

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Potassium
Sodium
Brain
Brain Death
Noise
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Double-quantum surface-coil NMR studies of sodium and potassium in the rat brain. / Lyon, R. C.; Pekar, James J; Moonen, C. T W; McLaughlin, A. C.

In: Magnetic Resonance in Medicine, Vol. 18, No. 1, 1991, p. 80-92.

Research output: Contribution to journalArticle

Lyon, R. C. ; Pekar, James J ; Moonen, C. T W ; McLaughlin, A. C. / Double-quantum surface-coil NMR studies of sodium and potassium in the rat brain. In: Magnetic Resonance in Medicine. 1991 ; Vol. 18, No. 1. pp. 80-92.
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