Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades

Marius Wipfli; Jacques Felblinger; Urs P. Mosimann; Christian W. Hess; Thomas E. Schlaepfer; René M. Müri

doi:10.1046/j.0953-816X.2001.01671.x

Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades

Marius Wipfli, Jacques Felblinger, Urs P. Mosimann, Christian W. Hess, Thomas E. Schlaepfer, René M. Müri

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.

Original language	English (US)
Pages (from-to)	571-575
Number of pages	5
Journal	European Journal of Neuroscience
Volume	14
Issue number	3
DOIs	https://doi.org/10.1046/j.0953-816X.2001.01671.x
State	Published - 2001
Externally published	Yes

Keywords

FEF
Humans
Saccades
TMS

ASJC Scopus subject areas

General Neuroscience

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10.1046/j.0953-816X.2001.01671.x

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title = "Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades",

abstract = "The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.",

keywords = "FEF, Humans, Saccades, TMS",

author = "Marius Wipfli and Jacques Felblinger and Mosimann, {Urs P.} and Hess, {Christian W.} and Schlaepfer, {Thomas E.} and M{\"u}ri, {Ren{\'e} M.}",

year = "2001",

doi = "10.1046/j.0953-816X.2001.01671.x",

language = "English (US)",

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AU - Wipfli, Marius

AU - Felblinger, Jacques

AU - Mosimann, Urs P.

AU - Hess, Christian W.

AU - Schlaepfer, Thomas E.

AU - Müri, René M.

PY - 2001

Y1 - 2001

N2 - The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.

AB - The study investigated the influence of double-pulse transcranial magnetic stimulation (dTMS) on memory-guided saccade triggering. Double pulses with interstimulus intervals (ISIs) of 35, 50, 65 or 80 ms were applied over the right frontal eye field (FEF) and as control over the occipital cortex. A significant dTMS effect was found exclusively for contralateral saccades; latency of memory-guided saccades was reduced after FEF stimulation with an ISI of 50 ms compared to latency without stimulation. This effect proved to be specific for the ISI of 50 ms over the FEF because control stimulation with the same ISI over the occipital cortex had no significant effect on latency of memory-guided saccades. The results of our study showed that, by using an appropriate ISI, dTMS is able to facilitate contralateral saccade triggering by stimulating the FEF. This suggests that TMS interferes specifically with saccade triggering mechanisms, probably by acting on presaccadic neurons of the FEF.

KW - FEF

KW - Humans

KW - Saccades

KW - TMS

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Double-pulse transcranial magnetic stimulation over the frontal eye field facilitates triggering of memory-guided saccades

Abstract

Keywords

ASJC Scopus subject areas

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