Double-positive with positive anti-glomerular basement membrane antibody and ANCA-positive disease in a patient with dermatomyositis

Eric J. Dein, Monica Crespo-Bosque, Homa Timlin, Duvuru Geetha

Research output: Contribution to journalArticle

Abstract

Approximately one in four patients (23.3%) with inflammatory myositis including dermatomyositis can require evaluation for acute kidney injury. The main cause of kidney injury is acute tubular necrosis from medications or myoglobinuria, though clinicians should be aware of a wide variety of possible aetiologies. We present the case of a 44-year-old woman with stable anti-Jo1 dermatomyositis, who presented with acute kidney injury. During her hospital course, she was diagnosed with double-positive disease characterised by circulating anti-glomerular basement membrane antibody and myeloperoxidase antineutrophil cytoplasmic antibody and renal biopsy revealing crescentic glomerulonephritis with linear staining of capillary wall for IgG.

Original languageEnglish (US)
Article number224475
JournalBMJ Case Reports
Volume2018
DOIs
StatePublished - Jan 1 2018

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Antineutrophil Cytoplasmic Antibodies
Glomerular Basement Membrane
Dermatomyositis
Acute Kidney Injury
Antibodies
Myoglobinuria
Myositis
Glomerulonephritis
Peroxidase
Necrosis
Immunoglobulin G
Staining and Labeling
Kidney
Biopsy

Keywords

  • muscle disease
  • vasculitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Double-positive with positive anti-glomerular basement membrane antibody and ANCA-positive disease in a patient with dermatomyositis. / Dein, Eric J.; Crespo-Bosque, Monica; Timlin, Homa; Geetha, Duvuru.

In: BMJ Case Reports, Vol. 2018, 224475, 01.01.2018.

Research output: Contribution to journalArticle

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