@article{c800233e287e4fbfaac7cd8b6ef9bda5,
title = "Double-Negative (PF4-Negative/SRA-Negative) Heparin-Induced Thrombocytopenia",
author = "Starke, {Samuel J.} and Streiff, {Michael B.} and Dannielle Brown and Ardian Latifi and Tijana Tuhy",
note = "Funding Information: Heparin-induced thrombocytopenia (HIT) is a disorder characterized by antibody-mediated platelet activation and vascular thrombosis in patients exposed to heparin. Traditionally, the diagnosis is supported by platelet-factor 4 (PF4)/heparin enzyme-immunoassay (EIA) and confirmed with a functional assay, like the serotonin release assay (SRA). We describe a patient with a clinical course highly suspicious for HIT despite an initially weakly positive, then negative, PF4 antibody and repeatedly negative SRA. This should alert clinicians to the growing evidence of double-negative (PF4 negative/SRA negative) HIT as a clinical entity. ",
year = "2023",
month = feb,
doi = "10.1016/j.amjmed.2022.09.023",
language = "English (US)",
volume = "136",
pages = "e32--e33",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",
}