Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: Two case reports and a review of literature

Leno Thomas, Judith Stamberg, Ivana Gojo, Yi Ning, Aaron P. Rapoport

Research output: Contribution to journalReview articlepeer-review

Abstract

Double minutes (dmin) are small, paired chromatin bodies that lack a centromere and represent a form of extrachromosomal gene amplification. Although they have been found in a variety of solid tumors, their presence in hematological malignancies, especially acute myeloid leukemia (AML), is rare. In addition, the presence of dmin may be a mechanism for upregulated oncogene expression and is generally associated with a poor prognosis. We describe two patients who had dmin at initial presentation of AML, including the first case of M5a with C-MYC amplification on dmin, and another case with C-MYC amplification as the only cytogenetic finding. We review here a total of 33 cases with dmin in AML. C-MYC was amplified by the dmin in 25 cases, while other putative oncogenes were amplified in the other 8.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalAmerican journal of hematology
Volume77
Issue number1
DOIs
StatePublished - Sep 1 2004

Keywords

  • AML
  • C-MYC
  • Double minutes
  • Gene amplification

ASJC Scopus subject areas

  • Hematology

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