Abstract
Double minutes (dmin) are small, paired chromatin bodies that lack a centromere and represent a form of extrachromosomal gene amplification. Although they have been found in a variety of solid tumors, their presence in hematological malignancies, especially acute myeloid leukemia (AML), is rare. In addition, the presence of dmin may be a mechanism for upregulated oncogene expression and is generally associated with a poor prognosis. We describe two patients who had dmin at initial presentation of AML, including the first case of M5a with C-MYC amplification on dmin, and another case with C-MYC amplification as the only cytogenetic finding. We review here a total of 33 cases with dmin in AML. C-MYC was amplified by the dmin in 25 cases, while other putative oncogenes were amplified in the other 8.
Original language | English (US) |
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Pages (from-to) | 55-61 |
Number of pages | 7 |
Journal | American journal of hematology |
Volume | 77 |
Issue number | 1 |
DOIs | |
State | Published - Sep 2004 |
Externally published | Yes |
Keywords
- AML
- C-MYC
- Double minutes
- Gene amplification
ASJC Scopus subject areas
- Hematology