Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media

Paul S. Lietman, Samuel E. McLinn, Frederick Goldberg, Robert Kramer, Elliott Saltstein, Jeffrey P. Bomze, Marc W. Deitch

Research output: Contribution to journalArticle

Abstract

A multicenter double-blind study of 363 pediatric outpatients with acute otitis media demonstrated that cyclacillin, administered in three divided doses (three times a day) for ten days, is as effective as and better tolerated than a similar regimen of amoxicillin. The bacteriologic cure rate for patients with middle-ear cultures was 98% in both treatment groups. Remission of signs and symptoms was significantly faster in the cyclacillin group (3.1 days) than in the amoxicillin group (4.3 days) (P

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalJournal of Pediatrics
Volume101
Issue number4
DOIs
StatePublished - 1982
Externally publishedYes

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Cyclacillin
Amoxicillin
Otitis Media
Middle Ear
Double-Blind Method
Signs and Symptoms
Outpatients
Pediatrics
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Lietman, P. S., McLinn, S. E., Goldberg, F., Kramer, R., Saltstein, E., Bomze, J. P., & Deitch, M. W. (1982). Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media. Journal of Pediatrics, 101(4), 617-621. https://doi.org/10.1016/S0022-3476(82)80724-5

Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media. / Lietman, Paul S.; McLinn, Samuel E.; Goldberg, Frederick; Kramer, Robert; Saltstein, Elliott; Bomze, Jeffrey P.; Deitch, Marc W.

In: Journal of Pediatrics, Vol. 101, No. 4, 1982, p. 617-621.

Research output: Contribution to journalArticle

Lietman, PS, McLinn, SE, Goldberg, F, Kramer, R, Saltstein, E, Bomze, JP & Deitch, MW 1982, 'Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media', Journal of Pediatrics, vol. 101, no. 4, pp. 617-621. https://doi.org/10.1016/S0022-3476(82)80724-5
Lietman, Paul S. ; McLinn, Samuel E. ; Goldberg, Frederick ; Kramer, Robert ; Saltstein, Elliott ; Bomze, Jeffrey P. ; Deitch, Marc W. / Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media. In: Journal of Pediatrics. 1982 ; Vol. 101, No. 4. pp. 617-621.
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