Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media

Paul S. Lietman, Samuel E. McLinn, Frederick Goldberg, Robert Kramer, Elliott Saltstein, Jeffrey P. Bomze, Marc W. Deitch

Research output: Contribution to journalArticle

Abstract

A multicenter double-blind study of 363 pediatric outpatients with acute otitis media demonstrated that cyclacillin, administered in three divided doses (three times a day) for ten days, is as effective as and better tolerated than a similar regimen of amoxicillin. The bacteriologic cure rate for patients with middle-ear cultures was 98% in both treatment groups. Remission of signs and symptoms was significantly faster in the cyclacillin group (3.1 days) than in the amoxicillin group (4.3 days) (P<0.05). Of the 179 children treated with cyclacillin, three (1.7%) had drug-related diarrhea in contrast to 18 of the 184 (9.8%) children treated with amoxicillin (P<0.01). Cyclacillin produces a rapid resolution of symptoms and a low incidence of diarrhea.

Original languageEnglish (US)
Pages (from-to)617-621
Number of pages5
JournalThe Journal of pediatrics
Volume101
Issue number4
DOIs
StatePublished - Oct 1982

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Lietman, P. S., McLinn, S. E., Goldberg, F., Kramer, R., Saltstein, E., Bomze, J. P., & Deitch, M. W. (1982). Double-blind multicenter comparison of cyclacillin and amoxicillin for the treatment of acute otitis media. The Journal of pediatrics, 101(4), 617-621. https://doi.org/10.1016/S0022-3476(82)80724-5