Dosing strategies for lithium monotherapy in children and adolescents with bipolar i disorder

Robert L Findling, Vivian Kafantaris, Mani Pavuluri, Nora K. McNamara, Jon McClellan, Jean A. Frazier, Linmarie Sikich, Robert Kowatch, Jacqui Lingler, Jon Faber, Brieana M. Rowles, Traci E. Clemons, Perdita Taylor-Zapata

Research output: Contribution to journalArticle

Abstract

Objective: The primary goal of this exploratory study was to obtain data that could lead to evidence-based dosing strategies for lithium in children and adolescents suffering from bipolar I disorder. Methods: Outpatients aged 7-17 years meeting Diagnostic and Statistical Manual of Mental Disorders, 4th edition, diagnostic criteria for bipolar I disorder (manic or mixed) were eligible for 8 weeks of open label treatment with lithium in one of three dosing arms. In Arm I, participants began treatment at a dose of 300 mg of lithium twice daily. The starting dose of lithium in Arms II and III was 300 mg thrice daily. Patients in Arms I and II could have their dose increased by 300 mg/day, depending on clinical response, at weekly visits. Patients in Arm III also had mid-week telephone interviews after which they could also have their dose of lithium increased by 300 mg per day. Youths weighing

Original languageEnglish (US)
Pages (from-to)195-205
Number of pages11
JournalJournal of Child and Adolescent Psychopharmacology
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

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Bipolar Disorder
Lithium
Diagnostic and Statistical Manual of Mental Disorders
Outpatients
Interviews
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

Cite this

Findling, R. L., Kafantaris, V., Pavuluri, M., McNamara, N. K., McClellan, J., Frazier, J. A., ... Taylor-Zapata, P. (2011). Dosing strategies for lithium monotherapy in children and adolescents with bipolar i disorder. Journal of Child and Adolescent Psychopharmacology, 21(3), 195-205. https://doi.org/10.1089/cap.2010.0084

Dosing strategies for lithium monotherapy in children and adolescents with bipolar i disorder. / Findling, Robert L; Kafantaris, Vivian; Pavuluri, Mani; McNamara, Nora K.; McClellan, Jon; Frazier, Jean A.; Sikich, Linmarie; Kowatch, Robert; Lingler, Jacqui; Faber, Jon; Rowles, Brieana M.; Clemons, Traci E.; Taylor-Zapata, Perdita.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 21, No. 3, 01.06.2011, p. 195-205.

Research output: Contribution to journalArticle

Findling, RL, Kafantaris, V, Pavuluri, M, McNamara, NK, McClellan, J, Frazier, JA, Sikich, L, Kowatch, R, Lingler, J, Faber, J, Rowles, BM, Clemons, TE & Taylor-Zapata, P 2011, 'Dosing strategies for lithium monotherapy in children and adolescents with bipolar i disorder', Journal of Child and Adolescent Psychopharmacology, vol. 21, no. 3, pp. 195-205. https://doi.org/10.1089/cap.2010.0084
Findling, Robert L ; Kafantaris, Vivian ; Pavuluri, Mani ; McNamara, Nora K. ; McClellan, Jon ; Frazier, Jean A. ; Sikich, Linmarie ; Kowatch, Robert ; Lingler, Jacqui ; Faber, Jon ; Rowles, Brieana M. ; Clemons, Traci E. ; Taylor-Zapata, Perdita. / Dosing strategies for lithium monotherapy in children and adolescents with bipolar i disorder. In: Journal of Child and Adolescent Psychopharmacology. 2011 ; Vol. 21, No. 3. pp. 195-205.
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