Dosing of contrast material to prevent contrast nephropathy in patients with renal disease

Ricardo G. Cigarroa, Richard A. Lange, Russel H. Williams, David Hillis

Research output: Contribution to journalArticlepeer-review


purpose; Contrast-induced renal dysfunction has been reported to occur in 15% to 42% of patients with underlying azotemia, but there is disagreement as to whether its incidence is reduced by limiting the amount of contrast material. To adjust the amount of contrast material to the severity of azotemia, we have utilized the following formula to calculate a contrast material "limit" in patients with renal disease:. Contrast material limit = 5 mL of contrast/kg body weight (maximum, 300 mL) serum creatinine (mg/dL). patients and methods: Over a 10-year period, 115 patients (53 men, 62 women, aged 61 ± 11 [mean ± SD] years) with renal dysfunction (baseline serum creatinine level greater than or equal to 1.8 mg/dL) underwent cardiac catherization and angiography, after which the level serum creatinine was measured daily for five days. The amount of contrast material that was given adhered to the limit in 86 patients (Group I) and exceeded it in 29 (Group II). results: Contrast-induced renal dysfunction (an increase in serum creatinine greater than or equal to 1.0 mg/dL) occurred in two (2%) patients in Group I and in six (21%) patients in Group II (p

Original languageEnglish (US)
Pages (from-to)649-652
Number of pages4
JournalAmerican Journal of Medicine
Issue numberC
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Nursing(all)


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