Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study

Kimberly P. Raghubar, Michael Lamba, Kim M. Cecil, Keith Owen Yeates, Ernest M Mahone, Christina Limke, David Grosshans, Travis J. Beckwith, M. Douglas Ris

Research output: Contribution to journalArticle

Abstract

Background: Advances in radiation treatment (RT), specifically volumetric planning with detailed dose and volumetric data for specific brain structures, have provided new opportunities to study neurobehavioral outcomes of RT in children treated for brain tumor. The present study examined the relationship between biophysical and physical dose metrics and neurocognitive ability, namely learning and memory, 2 years post-RT in pediatric brain tumor patients. Procedure: The sample consisted of 26 pediatric patients with brain tumor, 14 of whom completed neuropsychological evaluations on average 24 months post-RT. Prescribed dose and dose–volume metrics for specific brain regions were calculated including physical metrics (i.e., mean dose and maximum dose) and biophysical metrics (i.e., integral biological effective dose and generalized equivalent uniform dose). We examined the associations between dose–volume metrics (whole brain, right and left hippocampus), and performance on measures of learning and memory (Children's Memory Scale). Results: Biophysical dose metrics were highly correlated with the physical metric of mean dose but not with prescribed dose. Biophysical metrics and mean dose, but not prescribed dose, correlated with measures of learning and memory. Conclusions: These preliminary findings call into question the value of prescribed dose for characterizing treatment intensity; they also suggest that biophysical dose has only a limited advantage compared to physical dose when calculated for specific regions of the brain. We discuss the implications of the findings for evaluating and understanding the relation between RT and neurocognitive functioning.

Original languageEnglish (US)
Article numbere27245
JournalPediatric Blood and Cancer
Volume65
Issue number9
DOIs
StatePublished - Sep 1 2018

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Brain Neoplasms
Radiation
Pediatrics
Brain
Learning
Therapeutics
Aptitude
Hippocampus
Outcome Assessment (Health Care)

Keywords

  • dosimetry
  • late effects
  • learning and memory
  • pediatric brain tumor
  • radiation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients : A preliminary study. / Raghubar, Kimberly P.; Lamba, Michael; Cecil, Kim M.; Yeates, Keith Owen; Mahone, Ernest M; Limke, Christina; Grosshans, David; Beckwith, Travis J.; Ris, M. Douglas.

In: Pediatric Blood and Cancer, Vol. 65, No. 9, e27245, 01.09.2018.

Research output: Contribution to journalArticle

Raghubar, KP, Lamba, M, Cecil, KM, Yeates, KO, Mahone, EM, Limke, C, Grosshans, D, Beckwith, TJ & Ris, MD 2018, 'Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients: A preliminary study', Pediatric Blood and Cancer, vol. 65, no. 9, e27245. https://doi.org/10.1002/pbc.27245
Raghubar, Kimberly P. ; Lamba, Michael ; Cecil, Kim M. ; Yeates, Keith Owen ; Mahone, Ernest M ; Limke, Christina ; Grosshans, David ; Beckwith, Travis J. ; Ris, M. Douglas. / Dose–volume metrics and their relation to memory performance in pediatric brain tumor patients : A preliminary study. In: Pediatric Blood and Cancer. 2018 ; Vol. 65, No. 9.
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