Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery

Peijin Han, Pranav Lakshminarayanan, Wei Jiang, Ilya Shpitser, Xuan Hui, Sang Ho Lee, Zhi Cheng, Yue Guo, Russell H Taylor, Sauleh A. Siddiqui, Michael Bowers, Khadija Sheikh, Ana Ponce Kiess, Brandi Page, Junghoon Lee, Harry Quon, Todd McNutt

Research output: Contribution to journalArticle

Abstract

Xerostomia is a common consequence of radiotherapy in head and neck cancer. The objective was to compare the regional radiation dose distribution in patients that developed xerostomia within 6 months of radiotherapy and those recovered from xerostomia within 18 months post-radiotherapy. We developed a feature generation pipeline to extract dose volume histogram features from geometrically defined ipsilateral/contralateral parotid glands, submandibular glands, and oral cavity surrogates for each patient. Permutation tests with multiple comparisons were performed to assess the dose difference between injury vs. non-injury and recovery vs. non-recovery. Ridge logistic regression models were applied to predict injury and recovery using clinical features along with dose features (D10-D90) of the subvolumes extracted from oral cavity and salivary gland contours + 3 mm peripheral shell. Model performances were assessed by the area under the receiver operating characteristic curve (AUC) using nested cross-validation. We found that different regional dose/volume metrics patterns exist for injury vs. recovery. Compared to injury, recovery has increased importance to the subvolumes receiving lower dose. Within the subvolumes, injury tends to have increased importance towards D10 from D90. This suggests that different threshold for xerostomia injury and recovery. Injury is induced by the subvolumes receiving higher dose, and the ability to recover can be preserved by further reducing the dose to subvolumes receiving lower dose.

Original languageEnglish (US)
Article number3616
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Xerostomia
Salivary Glands
Wounds and Injuries
Radiotherapy
Mouth
Logistic Models
Submandibular Gland
Parotid Gland
Head and Neck Neoplasms
ROC Curve
Area Under Curve
Radiation

ASJC Scopus subject areas

  • General

Cite this

Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery. / Han, Peijin; Lakshminarayanan, Pranav; Jiang, Wei; Shpitser, Ilya; Hui, Xuan; Lee, Sang Ho; Cheng, Zhi; Guo, Yue; Taylor, Russell H; Siddiqui, Sauleh A.; Bowers, Michael; Sheikh, Khadija; Kiess, Ana Ponce; Page, Brandi; Lee, Junghoon; Quon, Harry; McNutt, Todd.

In: Scientific reports, Vol. 9, No. 1, 3616, 01.12.2019.

Research output: Contribution to journalArticle

Han, P, Lakshminarayanan, P, Jiang, W, Shpitser, I, Hui, X, Lee, SH, Cheng, Z, Guo, Y, Taylor, RH, Siddiqui, SA, Bowers, M, Sheikh, K, Kiess, AP, Page, B, Lee, J, Quon, H & McNutt, T 2019, 'Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery', Scientific reports, vol. 9, no. 1, 3616. https://doi.org/10.1038/s41598-019-40228-y
Han, Peijin ; Lakshminarayanan, Pranav ; Jiang, Wei ; Shpitser, Ilya ; Hui, Xuan ; Lee, Sang Ho ; Cheng, Zhi ; Guo, Yue ; Taylor, Russell H ; Siddiqui, Sauleh A. ; Bowers, Michael ; Sheikh, Khadija ; Kiess, Ana Ponce ; Page, Brandi ; Lee, Junghoon ; Quon, Harry ; McNutt, Todd. / Dose/Volume histogram patterns in Salivary Gland subvolumes influence xerostomia injury and recovery. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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