Dose response effects of lisdexamfetamine dimesylate treatment in adults with ADHD: An exploratory study

Stephen V. Faraone, Thomas J. Spencer, Scott H. Kollins, Stephen J. Glatt, David Goodman

Research output: Contribution to journalArticle

Abstract

Objective: To explore dose-response effects of lisdexamfetamine dimesylate (LDX) treatment for ADHD. Method: This was a 4-week, randomized, double-blinded, placebo-controlled, parallel-group, forced-dose titration study in adult participants, aged 18 to 55 years, meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.) criteria for ADHD. Results: Nearly all participants assigned to an LDX dose achieved their assigned dose with the exception of about 4% of participants assigned to the 50 mg or 14% assigned to the 70 mg doses. Higher doses of LDX led to greater improvements in ADHD-rating scale scores, independent of prior pharmacotherapy. This was evident for both inattentive and hyperactive-impulsive symptoms. The authors found some evidence for an interaction between LDX dose and baseline severity of ADHD symptoms. Conclusion: For LDX doses between 30 and 70 mg/d, the dose-response efficacy effect for LDX is not affected by prior pharmacotherapy, but patients with a greater severity of illness may benefit more from higher doses, especially for hyperactive-impulsive symptoms. The results do not provide information about doses above 70 mg/d, which is the maximum approved dose of LDX and the highest dose studied in ADHD clinical trials.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalJournal of Attention Disorders
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • ADHD
  • amphetamine
  • dose-response
  • lisdexamfetamine dimesylate
  • stimulants

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

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