Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis

Christopher Cox, Thomas W. Clarkson, David O. Marsh, Laman Amin-Zaki, Sa'adoun Tikriti, Gary G. Myers

Research output: Contribution to journalArticlepeer-review

Abstract

A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain longitudinal profiles recapitulating fetal exposure. Logit and hockey-stick models as well as nonparametric smoothing are used to describe data on delayed development and central nervous system abnormality.

Original languageEnglish (US)
Pages (from-to)318-332
Number of pages15
JournalEnvironmental research
Volume49
Issue number2
DOIs
StatePublished - Aug 1989
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

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