Dose-response analysis of infants prenatally exposed to methyl mercury: An application of a single compartment model to single-strand hair analysis

Christopher Cox, Thomas W. Clarkson, David O. Marsh, Laman Amin-Zaki, Sa'adoun Tikriti, Gary G. Myers

Research output: Contribution to journalArticle

Abstract

A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain longitudinal profiles recapitulating fetal exposure. Logit and hockey-stick models as well as nonparametric smoothing are used to describe data on delayed development and central nervous system abnormality.

Original languageEnglish (US)
Pages (from-to)318-332
Number of pages15
JournalEnvironmental Research
Volume49
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Mercury Poisoning
Hockey
Nervous System Malformations
Iraq
response analysis
Neurology
methylmercury
Mercury
hair
Hair
Disease Outbreaks
Central Nervous System
Fluorescence
X-Rays
X rays
nervous system
abnormality
poisoning
X-ray fluorescence
smoothing

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

Dose-response analysis of infants prenatally exposed to methyl mercury : An application of a single compartment model to single-strand hair analysis. / Cox, Christopher; Clarkson, Thomas W.; Marsh, David O.; Amin-Zaki, Laman; Tikriti, Sa'adoun; Myers, Gary G.

In: Environmental Research, Vol. 49, No. 2, 1989, p. 318-332.

Research output: Contribution to journalArticle

Cox, Christopher ; Clarkson, Thomas W. ; Marsh, David O. ; Amin-Zaki, Laman ; Tikriti, Sa'adoun ; Myers, Gary G. / Dose-response analysis of infants prenatally exposed to methyl mercury : An application of a single compartment model to single-strand hair analysis. In: Environmental Research. 1989 ; Vol. 49, No. 2. pp. 318-332.
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