Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine

Victor K. Wong, Rory Quagliata, Robert Adler, Kwang Sik-Kim

Research output: Contribution to journalArticle

Abstract

• We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)

Original languageEnglish (US)
Pages (from-to)734-741
Number of pages8
JournalAmerican Journal of Diseases of Children
Volume145
Issue number7
DOIs
StatePublished - Jul 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine'. Together they form a unique fingerprint.

  • Cite this