Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine

Victor K. Wong, Rory Quagliata, Robert Adler, Kwang Sik Kim

Research output: Contribution to journalArticle

Abstract

• We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)

Original languageEnglish (US)
Pages (from-to)734-741
Number of pages8
JournalAmerican Journal of Diseases of Children
Volume145
Issue number7
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Haemophilus influenzae type b
Conjugate Vaccines
Membrane Proteins
Vaccines
Anti-Idiotypic Antibodies
Age Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine. / Wong, Victor K.; Quagliata, Rory; Adler, Robert; Kim, Kwang Sik.

In: American Journal of Diseases of Children, Vol. 145, No. 7, 1991, p. 734-741.

Research output: Contribution to journalArticle

@article{3b013358c13e409cbac57d613006c9e0,
title = "Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine",
abstract = "• We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)",
author = "Wong, {Victor K.} and Rory Quagliata and Robert Adler and Kim, {Kwang Sik}",
year = "1991",
doi = "10.1001/archpedi.1991.02160070038018",
language = "English (US)",
volume = "145",
pages = "734--741",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Dose-Related Immunogenicity of Haemophilus influenzae Type b Capsular Polysaccharide—Neisseria meningitidis Outer Membrane Protein Conjugate Vaccine

AU - Wong, Victor K.

AU - Quagliata, Rory

AU - Adler, Robert

AU - Kim, Kwang Sik

PY - 1991

Y1 - 1991

N2 - • We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)

AB - • We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide—Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 μg of PRP. Overall, PRP-NOMP was highly immunogenic. Geometric mean titers of anti-PRP antibody increased from 0.09 to 3.3 mg/L and 6.6 mg/L following each dose of vaccine, respectively, in the 2- to 18-month age group. Similarly, anti-PRP antibody geometric mean titers increased from 0.12 to 5.9 mg/L in the older than 18-month age group. However, we noted an apparent inverse relationship between vaccine dosages and immune responses following two doses of PRP-NOMP in 2- to 18-month-old children. Anti-PRP antibody geometric mean titers were 12.0,6.9, and 3.5 mg/L, respectively, after the second dose of vaccine containing 7.5,15, or 30 μg of PRP. Additional studies are needed to understand the mechanisms responsible for this inverse relationship and also to determine the optimal dosage of PRP-NOMP for young children. (AJDC. 1991;145:742-745)

UR - http://www.scopus.com/inward/record.url?scp=84942185566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942185566&partnerID=8YFLogxK

U2 - 10.1001/archpedi.1991.02160070038018

DO - 10.1001/archpedi.1991.02160070038018

M3 - Article

C2 - 2058604

AN - SCOPUS:84942185566

VL - 145

SP - 734

EP - 741

JO - JAMA Pediatrics

JF - JAMA Pediatrics

SN - 2168-6203

IS - 7

ER -