Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia

J. R. Farah, P. O. Kwiterovich, C. A. Neill

Research output: Contribution to journalArticle

Abstract

Twenty children and young adults with familial hypercholesterolemia (FH), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low density lipoprotein (LDL) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and LDL cholesterol, and body weight. When the dose of cholestyramine was increased in 13 patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and LDL cholesterol fell within the normal range in 11 subjects (average dose, 7 g/day), and the response was directly proportional (P

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalThe Lancet
Volume1
Issue number8002
StatePublished - 1977

Fingerprint

Cholestyramine Resin
Hyperlipoproteinemia Type II
Young Adult
Cholesterol
LDL Cholesterol
Reference Values
Fats
Body Weight
Diet
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Farah, J. R., Kwiterovich, P. O., & Neill, C. A. (1977). Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia. The Lancet, 1(8002), 59-63.

Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia. / Farah, J. R.; Kwiterovich, P. O.; Neill, C. A.

In: The Lancet, Vol. 1, No. 8002, 1977, p. 59-63.

Research output: Contribution to journalArticle

Farah, JR, Kwiterovich, PO & Neill, CA 1977, 'Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia', The Lancet, vol. 1, no. 8002, pp. 59-63.
Farah, J. R. ; Kwiterovich, P. O. ; Neill, C. A. / Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia. In: The Lancet. 1977 ; Vol. 1, No. 8002. pp. 59-63.
@article{9b9482bbeb1d4e63a03fb9b6232d6618,
title = "Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia",
abstract = "Twenty children and young adults with familial hypercholesterolemia (FH), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low density lipoprotein (LDL) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and LDL cholesterol, and body weight. When the dose of cholestyramine was increased in 13 patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and LDL cholesterol fell within the normal range in 11 subjects (average dose, 7 g/day), and the response was directly proportional (P",
author = "Farah, {J. R.} and Kwiterovich, {P. O.} and Neill, {C. A.}",
year = "1977",
language = "English (US)",
volume = "1",
pages = "59--63",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8002",

}

TY - JOUR

T1 - Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia

AU - Farah, J. R.

AU - Kwiterovich, P. O.

AU - Neill, C. A.

PY - 1977

Y1 - 1977

N2 - Twenty children and young adults with familial hypercholesterolemia (FH), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low density lipoprotein (LDL) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and LDL cholesterol, and body weight. When the dose of cholestyramine was increased in 13 patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and LDL cholesterol fell within the normal range in 11 subjects (average dose, 7 g/day), and the response was directly proportional (P

AB - Twenty children and young adults with familial hypercholesterolemia (FH), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low density lipoprotein (LDL) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and LDL cholesterol, and body weight. When the dose of cholestyramine was increased in 13 patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and LDL cholesterol fell within the normal range in 11 subjects (average dose, 7 g/day), and the response was directly proportional (P

UR - http://www.scopus.com/inward/record.url?scp=0017345317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017345317&partnerID=8YFLogxK

M3 - Article

C2 - 63709

VL - 1

SP - 59

EP - 63

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8002

ER -