Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia

J. R. Farah, P. O. Kwiterovich, C. A. Neill

Research output: Contribution to journalArticle

Abstract

Twenty children and young adults with familial hypercholesterolemia (FH), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low density lipoprotein (LDL) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and LDL cholesterol, and body weight. When the dose of cholestyramine was increased in 13 patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and LDL cholesterol fell within the normal range in 11 subjects (average dose, 7 g/day), and the response was directly proportional (P

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalThe Lancet
Volume1
Issue number8002
StatePublished - 1977

ASJC Scopus subject areas

  • Medicine(all)

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    Farah, J. R., Kwiterovich, P. O., & Neill, C. A. (1977). Dose effect relation of cholestyramine in children and young adults with familial hypercholesterolaemia. The Lancet, 1(8002), 59-63.