DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA

J. Ramsay Farah; PeterO Kwiterovich; CatherineA Neill

doi:10.1016/S0140-6736(77)91078-9

DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA

J. Ramsay Farah, PeterO Kwiterovich, CatherineA Neill

School of Medicine

Research output: Contribution to journal › Article

Abstract

Twenty children and young adults with familial hypercholesterolæmia (F.H.), on a diet low in cholesterol and high in polyunsaturated fats, were treated with cholestyramine in a metabolic unit to determine the decrease in plasma cholesterol and low-density lipoprotein (L.D.L.) cholesterol in relation to drug dosage, pretreatment concentrations of cholesterol and L.D.L. cholesterol, and body-weight. When the dose of cholestyramine was increased in thirteen patients by 1 g/day up to 16 g/day, given twice daily, cholesterol and L.D.L. cholesterol fell within the normal range in eleven subjects (average dose, 7 g/day), and the response was directly proportional (P<

Original language	English (US)
Pages (from-to)	59-63
Number of pages	5
Journal	The Lancet
Volume	309
Issue number	8002
DOIs	https://doi.org/10.1016/S0140-6736(77)91078-9
State	Published - Jan 8 1977

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Cholestyramine Resin

Young Adult

Cholesterol

LDL Cholesterol

Reference Values

Fats

Body Weight

Diet

Pharmaceutical Preparations

ASJC Scopus subject areas

Medicine(all)

Cite this

Ramsay Farah, J., Kwiterovich, P., & Neill, C. (1977). DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA. The Lancet, 309(8002), 59-63. https://doi.org/10.1016/S0140-6736(77)91078-9

DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA. / Ramsay Farah, J.; Kwiterovich, PeterO; Neill, CatherineA.

In: The Lancet, Vol. 309, No. 8002, 08.01.1977, p. 59-63.

Research output: Contribution to journal › Article

Ramsay Farah, J, Kwiterovich, P & Neill, C 1977, 'DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA', The Lancet, vol. 309, no. 8002, pp. 59-63. https://doi.org/10.1016/S0140-6736(77)91078-9

Ramsay Farah J, Kwiterovich P, Neill C. DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA. The Lancet. 1977 Jan 8;309(8002):59-63. https://doi.org/10.1016/S0140-6736(77)91078-9

Ramsay Farah, J. ; Kwiterovich, PeterO ; Neill, CatherineA. / DOSE-EFFECT RELATION OF CHOLESTYRAMINE IN CHILDREN AND YOUNG ADULTS WITH FAMILIAL HYPERCHOLESTEROLÆMIA. In: The Lancet. 1977 ; Vol. 309, No. 8002. pp. 59-63.

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10.1016/S0140-6736(77)91078-9